Measurements of immature platelets with haematology analysers are of limited value to separate immune thrombocytopenia from bone marrow failure

Journal article


Publication Details

Author(s): Cybulska A, Meintker L, Ringwald J, Krause S
Journal: British Journal of Haematology
Publication year: 2017
Volume: 177
Journal issue: 4
Pages range: 612-619
ISSN: 0007-1048


Abstract


Detection of immature platelets in the circulation may help to dissect thrombocytopenia due to platelet destruction from bone marrow failure (BMF). We prospectively tested the predictive value of immature platelets, measured as immature platelet fraction (IPF) on the XE-5000 (Sysmex, Kobe, Japan) or percentage of reticulated platelets (rPT) on the CD Sapphire (Abbott Diagnostics, Santa Clara, CA, USA) to separate immune thrombocytopenia (ITP) from BMF (leukaemia, myelodysplastic syndrome, aplastic anaemia). We analysed 58 samples of patients with BMF, 47 samples of patients with ITP and 97 controls. Median rPT (CD Sapphire) was increased to 9·0% in ITP and to 10·9% in BMF, compared to 1·9% in controls. Median IPF (XE-5000) was 16·2% in ITP, 10·2% in BMF and 2·5% in controls. We found an inverse correlation between high fractions of immature platelets and low platelet counts in thrombocytopenic samples regardless of the diagnosis. In conclusion, we observed a broad overlap of immature platelets between ITP and BMF, which may be caused by an accelerated release of immature platelets in any thrombocytopenic state and decreased production in many patients with ITP. Despite this, IPF (XE-5000) had some power to discriminate ITP from BMF, whereas rPT (CD Sapphire) was of no predictive value.



FAU Authors / FAU Editors

Cybulska, Annalina
Medizinische Fakultät
Krause, Stefan Prof. Dr.
Medizinische Klinik 5 - Hämatologie und Internistische Onkologie
Meintker, Lisa Dr. med.
Medizinische Klinik 5 - Hämatologie und Internistische Onkologie


How to cite

APA:
Cybulska, A., Meintker, L., Ringwald, J., & Krause, S. (2017). Measurements of immature platelets with haematology analysers are of limited value to separate immune thrombocytopenia from bone marrow failure. British Journal of Haematology, 177(4), 612-619. https://dx.doi.org/10.1111/bjh.14628

MLA:
Cybulska, Annalina, et al. "Measurements of immature platelets with haematology analysers are of limited value to separate immune thrombocytopenia from bone marrow failure." British Journal of Haematology 177.4 (2017): 612-619.

BibTeX: 

Last updated on 2018-08-10 at 02:25