Development and characterization of lithium-releasing silicate bioactive glasses and their scaffolds for bone repair

Journal article
(Original article)


Publication Details

Author(s): Miguez Pacheco V, Büttner T, Macon ALB, Jones JR, Fey T, de Ligny D, Greil P, Chevalier J, Malchere A, Boccaccini AR
Journal: Journal of Non-Crystalline Solids
Publisher: Elsevier
Publication year: 2016
Volume: 432
Journal issue: Part A
Pages range: 65-72
ISSN: 0022-3093
Language: English


Abstract


Incorporation of therapeutic ions into the structure of bioactive glasses for direct stimulation of cells is a very attractive approach for tissue engineering strategies. Lithium has recently been identified as a biologically active ion which can stimulate osteoblast cell activity. In this study, lithium-containing bioactive glasses (Li-BGs) where Li2O substitutes Na2O in different amounts (2.5, 5 and 10 wt.% Li2O) in 45S5 bioactive glass (BC) were produced and made into 3D scaffolds by the foam replica method. The structural changes that occur after heat treatment, the effect of lithium-content on the bioactivity of the glasses and their lithium ion release profiles were investigated. The results show that the novel Li-BC formulations exhibit the formation of an apatite-like layer on their surface after immersion in SBF for 1 day thus confirming their high surface reactivity, similar to undoped 45S5 BC. XRD results showed that the Li-doped BGs crystallize mainly to combeite (Na2Ca2Si3O9) and silicorhenanite (SiO4(PO4)(2)Ca-5) but also Li6P6O18 and Li3PO4 phases were detected. In terms of lithium ion release, the formulations at 2.5 wt.% and 5 wt.% Li2O content were the only ones to be within the therapeutic range (<83 ppm). (C) 2015 Elsevier B.V. All rights reserved.



FAU Authors / FAU Editors

Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Büttner, Teresa
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
de Ligny, Dominique Prof. Dr.
Professur für Werkstoffwissenschaften (Glas und Keramik)
Fey, Tobias Dr.
Lehrstuhl für Werkstoffwissenschaften (Glas und Keramik)
Greil, Peter Prof. Dr.
Lehrstuhl für Werkstoffwissenschaften (Glas und Keramik)
Miguez Pacheco, Valentina
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)


External institutions
Imperial College London / The Imperial College of Science, Technology and Medicine
MATEIS


How to cite

APA:
Miguez Pacheco, V., Büttner, T., Macon, A.L.B., Jones, J.R., Fey, T., de Ligny, D.,... Boccaccini, A.R. (2016). Development and characterization of lithium-releasing silicate bioactive glasses and their scaffolds for bone repair. Journal of Non-Crystalline Solids, 432(Part A), 65-72. https://dx.doi.org/10.1016/j.jnoncrysol.2015.03.027

MLA:
Miguez Pacheco, Valentina, et al. "Development and characterization of lithium-releasing silicate bioactive glasses and their scaffolds for bone repair." Journal of Non-Crystalline Solids 432.Part A (2016): 65-72.

BibTeX: 

Last updated on 2018-07-08 at 12:38