Recovering the superficial microvascular pattern via diffuse reflection imaging: phantom validation

Journal article
(Review article)


Publication Details

Author(s): Chen C, Klämpfl F, Kanawade R, Riemann M, Knipfer C, Stelzle F, Schmidt M
Journal: Biomedical Engineering Online
Publisher: BioMed Central
Publication year: 2015
Volume: 14
Journal issue: 1
Pages range: 87 - 101
ISSN: 1475-925X
Language: English


Abstract


Background



Diffuse reflection imaging could potentially be used to recover the superficial microvasculature under cutaneous tissue and the associated blood oxygenation status with a modified imaging resolution. The aim of this work is to deliver a new approach of local off-axis scanning diffuse reflection imaging, with the revisit of the modified Beer–Lambert Law (MBLL).



Methods



To validate this, the system is used to recover the micron-scale subsurface vessel structure interiorly embedded in a skin equivalent tissue phantom. This vessel structure is perfused with oxygenated meta-hemoglobin solution.



Results



Our preliminary results confirm that the thin vessel structure can be mapped into a 2-D planar image. The distributions of oxygenated hemoglobin concentration (<a onClick="popup('http://www.biomedical-engineering-online.com/content/14/1/87/mathml/M1','MathML',630,470);return false;" target="_blank" data-cke-saved-href="http://www.biomedical-engineering-online.com/content/14/1/87/mathml/M1" href="http://www.biomedical-engineering-online.com/content/14/1/87/mathml/M1">View MathML</a>) and deoxygenated hemoglobin concentration (<a onClick="popup('http://www.biomedical-engineering-online.com/content/14/1/87/mathml/M2','MathML',630,470);return false;" target="_blank" data-cke-saved-href="http://www.biomedical-engineering-online.com/content/14/1/87/mathml/M2" href="http://www.biomedical-engineering-online.com/content/14/1/87/mathml/M2">View MathML</a>) can be co-registerated through the MBLL upon the CW spectroscopy, the scattering issue is addressed in the reformed MBLL. The recovered pattern matches to the estimation from the simultaneous optical coherence tomography studies.



Conclusions



With further modification, this system may serve as the first prototype to investigate the superficial microvasculature in the expotential skin cancer loci, or a micro-lesion of vascular dermatosis.



FAU Authors / FAU Editors

Chen, Chen
Lehrstuhl für Photonische Technologien
Kanawade, Rajesh
Lehrstuhl für Photonische Technologien
Klämpfl, Florian Dr.-Ing.
Lehrstuhl für Photonische Technologien
Riemann, Max
Medizinische Fakultät
Schmidt, Michael Prof. Dr.-Ing.
Lehrstuhl für Photonische Technologien


How to cite

APA:
Chen, C., Klämpfl, F., Kanawade, R., Riemann, M., Knipfer, C., Stelzle, F., & Schmidt, M. (2015). Recovering the superficial microvascular pattern via diffuse reflection imaging: phantom validation. Biomedical Engineering Online, 14(1), 87 - 101. https://dx.doi.org/10.1186/s12938-015-0081-x

MLA:
Chen, Chen, et al. "Recovering the superficial microvascular pattern via diffuse reflection imaging: phantom validation." Biomedical Engineering Online 14.1 (2015): 87 - 101.

BibTeX: 

Last updated on 2018-13-07 at 08:10