A novel microfluidic model to mimic turbid nature and microvasculature of cutaneous tissue for optical imaging experiments

Journal article
(Review article)


Publication Details

Author(s): Chen C, Ahmed M, Klämpfl F, Stelzle F, Schmidt M
Journal: Proceedings- Spie the International Society for Optical Engineering
Publisher: International Society for Optical Engineering; 1999
Publication year: 2015
Volume: 9792
Journal issue: 97920J
ISSN: 0277-786X
Language: English


Abstract


To provide clinically relevant insights into the device performance of an optical imaging approach to reconstruct the superficial cutaneous micro-circulation (skin angiography), a phantom device with turbid matrix and perfusable micro-vessels is essential. In this work, we describe a novel microfluidic-based device to mimic the micro-vessels and the turbid nature of the epidermis and dermis. This phantom device contains a hollow assay with a diameter of the channels of 50 μm. The hollow assay includes the geometry of the inlet, the river-like assay, and the outlet, which can be perfused by e.g. meta-hemoglobin solution. This imitates the superficial micro-circulation in the skin. The absorption coefficient μa and the reduced scattering coefficient μs' are adjusted to match those of skin. As an application case, we attempt to reconstruct a 2-D velocity field of the hemoglobin flow in the scattering microfluidic device via the Doppler-mode of an OCT.



FAU Authors / FAU Editors

Chen, Chen
Lehrstuhl für Photonische Technologien
Klämpfl, Florian Dr.-Ing.
Lehrstuhl für Photonische Technologien
Schmidt, Michael Prof. Dr.-Ing.
Lehrstuhl für Photonische Technologien


How to cite

APA:
Chen, C., Ahmed, M., Klämpfl, F., Stelzle, F., & Schmidt, M. (2015). A novel microfluidic model to mimic turbid nature and microvasculature of cutaneous tissue for optical imaging experiments. Proceedings- Spie the International Society for Optical Engineering, 9792(97920J). https://dx.doi.org/10.1117/12.2203446

MLA:
Chen, Chen, et al. "A novel microfluidic model to mimic turbid nature and microvasculature of cutaneous tissue for optical imaging experiments." Proceedings- Spie the International Society for Optical Engineering 9792.97920J (2015).

BibTeX: 

Last updated on 2018-22-06 at 05:23