Golditz T, Steib S, Pfeifer K, Uder M, Gelse K, Janka RM, Hennig F, Welsch G (2014)
Publication Type: Journal article
Publication year: 2014
Publisher: Elsevier
Book Volume: 22
Pages Range: 1377 - 1385
Journal Issue: 10
DOI: 10.1016/j.joca.2014.04.029
Objective: The aim of this study was to investigate, using T2-mapping, the impact of functional instability in the ankle joint on the development of early cartilage damage. Methods: Ethical approval for this study was provided. Thirty-six volunteers from the university sports program were divided into three groups according to their ankle status: functional ankle instability (FAI, initial ankle sprain with residual instability); ankle sprain Copers (initial sprain, without residual instability); and controls (without a history of ankle injuries). Quantitative T2-mapping magnetic resonance imaging (MRI) was performed at the beginning ('early-unloading') and at the end ('late-unloading') of the MR-examination, with a mean time span of 27min. Zonal region-of-interest T2-mapping was performed on the talar and tibial cartilage in the deep and superficial layers. The inter-group comparisons of T2-values were analyzed using paired and unpaired t-tests. Statistical analysis of variance was performed. Results: T2-values showed significant to highly significant differences in 11 of 12 regions throughout the groups. In early-unloading, the FAI-group showed a significant increase in quantitative T2-values in the medial, talar regions (. P=0.008, P=0.027), whereas the Coper-group showed this enhancement in the central-lateral regions (. P=0.05). Especially the comparison of early-loading to late-unloading values revealed significantly decreasing T2-values over time laterally and significantly increasing T2-values medially in the FAI-group, which were not present in the Coper- or control-group. Conclusion: Functional instability causes unbalanced loading in the ankle joint, resulting in cartilage alterations as assessed by quantitative T2-mapping. This approach can visualize and localize early cartilage abnormalities, possibly enabling specific treatment options to prevent osteoarthritis in young athletes.
APA:
Golditz, T., Steib, S., Pfeifer, K., Uder, M., Gelse, K., Janka, R.M.,... Welsch, G. (2014). Functional ankle instability as a risk factor for osteoarthritis: Using T2-mapping to analyze early cartilage degeneration in the ankle joint of young athletes. Osteoarthritis and Cartilage, 22(10), 1377 - 1385. https://doi.org/10.1016/j.joca.2014.04.029
MLA:
Golditz, Tobias, et al. "Functional ankle instability as a risk factor for osteoarthritis: Using T2-mapping to analyze early cartilage degeneration in the ankle joint of young athletes." Osteoarthritis and Cartilage 22.10 (2014): 1377 - 1385.
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