Tetracycline-encapsulated P(3HB) microsphere-coated 45S5 Bioglass®-based scaffolds for bone tissue engineering

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Meng D, Francis L, Thompson ID, Mierke C, Hübner H, Amtmann A, Roy I, Boccaccini AR
Zeitschrift: Journal of Materials Science-Materials in Medicine
Verlag: Springer Verlag (Germany)
Jahr der Veröffentlichung: 2013
Band: 24
Heftnummer: 12
Seitenbereich: 2809-2817
ISSN: 0957-4530


Abstract


Bioglass®-based scaffolds for bone tissue engineering have been developed, which can also serve as carriers for drug delivery. For this, P(3HB) microspheres (PMSs) loaded with tetracycline were fabricated and immobilised on the scaffold surfaces by a modified slurry dipping technique. The sustained drug delivery ability in simulated body fluid was confirmed by using UV-Vis absorption spectroscopy measurements. The MTT assay using mouse fibroblast cells provided evidence that the tetracycline loaded microspheres produced in this study show limited cytotoxicity. The scaffolds developed in this work provide mechanical support, adequate 3D surface roughness, bioactivity and controlled drug delivery function, and are thus interesting candidates for bone tissue engineering applications. © 2013 Springer Science+Business Media New York.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Hübner, Holger Dr.-Ing.
Lehrstuhl für Bioverfahrenstechnik


Einrichtungen weiterer Autorinnen und Autoren

Imperial College London / The Imperial College of Science, Technology and Medicine
King’s College London
University of Westminster


Zitierweisen

APA:
Meng, D., Francis, L., Thompson, I.D., Mierke, C., Hübner, H., Amtmann, A.,... Boccaccini, A.R. (2013). Tetracycline-encapsulated P(3HB) microsphere-coated 45S5 Bioglass®-based scaffolds for bone tissue engineering. Journal of Materials Science-Materials in Medicine, 24(12), 2809-2817. https://dx.doi.org/10.1007/s10856-013-5012-4

MLA:
Meng, D., et al. "Tetracycline-encapsulated P(3HB) microsphere-coated 45S5 Bioglass®-based scaffolds for bone tissue engineering." Journal of Materials Science-Materials in Medicine 24.12 (2013): 2809-2817.

BibTeX: 

Zuletzt aktualisiert 2018-07-08 um 06:24