Tetracycline-encapsulated P(3HB) microsphere-coated 45S5 Bioglass®-based scaffolds for bone tissue engineering

Meng D, Francis L, Thompson ID, Mierke C, Hübner H, Amtmann A, Roy I, Boccaccini AR (2013)

Publication Type: Journal article

Publication year: 2013

Journal

Journal of Materials Science: Materials in Medicine Springer

Publisher: Springer Verlag (Germany)

Book Volume: 24

Pages Range: 2809-2817

Journal Issue: 12

DOI: 10.1007/s10856-013-5012-4

Abstract

Bioglass®-based scaffolds for bone tissue engineering have been developed, which can also serve as carriers for drug delivery. For this, P(3HB) microspheres (PMSs) loaded with tetracycline were fabricated and immobilised on the scaffold surfaces by a modified slurry dipping technique. The sustained drug delivery ability in simulated body fluid was confirmed by using UV-Vis absorption spectroscopy measurements. The MTT assay using mouse fibroblast cells provided evidence that the tetracycline loaded microspheres produced in this study show limited cytotoxicity. The scaffolds developed in this work provide mechanical support, adequate 3D surface roughness, bioactivity and controlled drug delivery function, and are thus interesting candidates for bone tissue engineering applications. © 2013 Springer Science+Business Media New York.

Authors with CRIS profile

Holger Hübner Lehrstuhl für Bioverfahrenstechnik Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

University of Westminster GB United Kingdom (GB) Imperial College London / The Imperial College of Science, Technology and Medicine GB United Kingdom (GB) King’s College London GB United Kingdom (GB)

How to cite

APA:

Meng, D., Francis, L., Thompson, I.D., Mierke, C., Hübner, H., Amtmann, A.,... Boccaccini, A.R. (2013). Tetracycline-encapsulated P(3HB) microsphere-coated 45S5 Bioglass®-based scaffolds for bone tissue engineering. Journal of Materials Science: Materials in Medicine, 24(12), 2809-2817. https://dx.doi.org/10.1007/s10856-013-5012-4

MLA:

Meng, D., et al. "Tetracycline-encapsulated P(3HB) microsphere-coated 45S5 Bioglass®-based scaffolds for bone tissue engineering." Journal of Materials Science: Materials in Medicine 24.12 (2013): 2809-2817.

BibTeX: Download