Presence of HLA-B27 is associated with changes of serum levels of mediators of the Wnt and hedgehog pathway

Aschermann S, Englbrecht M, Bergua A, Spriewald BM, Said-Nahal R, Breban M, Schett G, Rech J (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Joint Bone Spine Elsevier Masson

Book Volume: 83

Pages Range: 43-6

Journal Issue: 1

DOI: 10.1016/j.jbspin.2015.03.019

Abstract

HLA-B27 is present in 5% of the Caucasian population and is strongly associated with the development of spondyloarthritis (SpA), a disease characterized by inflammation and substantial bone changes. We hypothesized that the presence of HLA-B27 in itself is associated with alterations of key regulatory of bone homeostasis.Sera of 241 individuals were assessed for the serum levels of Wnt pathway regulators, sclerostin and dickkopf (Dkk)-1 as well as Indian hedgehog (IHH) and collagen type I cleavage products (CTX1). Of the 151 HLA-B27+ subjects, 31 had SpA, 30 had anterior uveitis, 30 were healthy individuals and 60 healthy siblings of patients with SpA.Sclerostin levels were significantly (P<0.001) lower in HLA-B27+ subjects (314±21pg/mL) compared to HLA-B27 negative controls (mean±SEM: 492±30pg/mL), no matter if subjects were either healthy, or affected by SpA or uveitis. Similar results were found for Dkk-1. No differences between the groups with respect to the bone resorption marker CTX1 were found. In contrast, IHH levels were significantly (P<0.001) higher in the carriers of HLA-B27 than in the negative controls.Changes in key regulators of the Wnt pathway as well as IHH, a molecule regulating endochondral ossification, are found in HLA-B27 carriers, independent if they were healthy or affected by uveitis or SpA.

Authors with CRIS profile

Sarah Aschermann Lehrstuhl für Innere Medizin III Matthias Englbrecht Lehrstuhl für Innere Medizin III Georg Schett Lehrstuhl für Innere Medizin III

Involved external institutions

Versailles Saint-Quentin-en-Yvelines University / Université de Versailles Saint-Quentin-en-Yvelines (UVSQ) FR France (FR)

How to cite

APA:

Aschermann, S., Englbrecht, M., Bergua, A., Spriewald, B.M., Said-Nahal, R., Breban, M.,... Rech, J. (2016). Presence of HLA-B27 is associated with changes of serum levels of mediators of the Wnt and hedgehog pathway. Joint Bone Spine, 83(1), 43-6. https://dx.doi.org/10.1016/j.jbspin.2015.03.019

MLA:

Aschermann, Sarah, et al. "Presence of HLA-B27 is associated with changes of serum levels of mediators of the Wnt and hedgehog pathway." Joint Bone Spine 83.1 (2016): 43-6.

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