Duration of lithium treatment and brain lithium concentration in patients with unipolar and schizoaffective disorder: A study with magnetic resonance spectroscopy

Journal article


Publication Details

Author(s): Riedl U, Barocka A, Kolem H, Demling J, Kaschka WP, Schelp R, Stemmler M, Ebert D
Journal: Biological Psychiatry
Publisher: Elsevier
Publication year: 1997
Volume: 41
Pages range: 844-850
ISSN: 0006-3223


Abstract


Twenty psychiatric patients on lithium medication were examined with 7-Li-magnetic resonance spectroscopy of the brain. Patients on long-term lithium treatment (>6 months) were compared with a short-term group who had been taking lithium for between 4 and 8 weeks. Patients met DSM-III-R criteria for either recurrent unipolar depressive disorder (DSM-III-R 296.3x) or schizoaffective disorder, depressive type (DSM-III-R 295.70). The brain:serum lithium ratio was 0.76 ± 0.26; there was no significant difference between short-term and long-term treatment. In the group of long-term treatment patients there was a positive correlation between lithium dose per day and brain lithium concentration (R = .72, p <.01), and between lithium plasma concentration and brain lithium concentration (R = .65, p < .05). In the short-term group, however, there was no significant correlation for these parameters. No differences between unipolar and schizoaffective disorder were found.



FAU Authors / FAU Editors

Stemmler, Mark Prof.
Lehrstuhl für Psychologische Diagnostik, Methodenlehre und Rechtspsychologie


External institutions
Siemens AG, Healthcare Sector
Universität Ulm


How to cite

APA:
Riedl, U., Barocka, A., Kolem, H., Demling, J., Kaschka, W.P., Schelp, R.,... Ebert, D. (1997). Duration of lithium treatment and brain lithium concentration in patients with unipolar and schizoaffective disorder: A study with magnetic resonance spectroscopy. Biological Psychiatry, 41, 844-850. https://dx.doi.org/10.1016/S0006-3223(96)00330-7

MLA:
Riedl, Ulrich, et al. "Duration of lithium treatment and brain lithium concentration in patients with unipolar and schizoaffective disorder: A study with magnetic resonance spectroscopy." Biological Psychiatry 41 (1997): 844-850.

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Last updated on 2018-08-07 at 18:10