Duration of lithium treatment and brain lithium concentration in patients with unipolar and schizoaffective disorder: A study with magnetic resonance spectroscopy

Riedl U, Barocka A, Kolem H, Demling J, Kaschka WP, Schelp R, Stemmler M, Ebert D (1997)

Publication Type: Journal article

Publication year: 1997

Journal

Biological Psychiatry Elsevier

Publisher: Elsevier

Book Volume: 41

Pages Range: 844-850

DOI: 10.1016/S0006-3223(96)00330-7

Abstract

Twenty psychiatric patients on lithium medication were examined with 7-Li-magnetic resonance spectroscopy of the brain. Patients on long-term lithium treatment (>6 months) were compared with a short-term group who had been taking lithium for between 4 and 8 weeks. Patients met DSM-III-R criteria for either recurrent unipolar depressive disorder (DSM-III-R 296.3x) or schizoaffective disorder, depressive type (DSM-III-R 295.70). The brain:serum lithium ratio was 0.76 ± 0.26; there was no significant difference between short-term and long-term treatment. In the group of long-term treatment patients there was a positive correlation between lithium dose per day and brain lithium concentration (R = .72, p <.01), and between lithium plasma concentration and brain lithium concentration (R = .65, p < .05). In the short-term group, however, there was no significant correlation for these parameters. No differences between unipolar and schizoaffective disorder were found.

Authors with CRIS profile

Mark Stemmler Lehrstuhl für Psychologische Diagnostik, Methodenlehre und Rechtspsychologie

Involved external institutions

Siemens AG, Healthcare Sector DE Germany (DE) Universität Ulm DE Germany (DE)

How to cite

APA:

Riedl, U., Barocka, A., Kolem, H., Demling, J., Kaschka, W.P., Schelp, R.,... Ebert, D. (1997). Duration of lithium treatment and brain lithium concentration in patients with unipolar and schizoaffective disorder: A study with magnetic resonance spectroscopy. Biological Psychiatry, 41, 844-850. https://dx.doi.org/10.1016/S0006-3223(96)00330-7

MLA:

Riedl, Ulrich, et al. "Duration of lithium treatment and brain lithium concentration in patients with unipolar and schizoaffective disorder: A study with magnetic resonance spectroscopy." Biological Psychiatry 41 (1997): 844-850.

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