Quantification of change in vocal fold tissue stiffness relative to depth of artificial damage

Rohlfs AK, Schmolke S, Clauditz T, Hess M, Mueller F, Pueschel K, Roemer F, Schumacher U, Goodyer E (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Logopedics Phoniatrics Vocology Informa Healthcare

Book Volume: 42

Pages Range: 108-117

Journal Issue: 3

DOI: 10.1080/14015439.2016.1221445

Abstract

To quantify changes in the biomechanical properties of human excised vocal folds with defined artificial damage.The linear skin rheometer (LSR) was used to obtain a series of rheological measurements of shear modulus from the surface of 30 human cadaver vocal folds. The tissue samples were initially measured in a native condition and then following varying intensities of thermal damage. Histological examination of each vocal fold was used to determine the depth of artificial alteration. The measured changes in stiffness were correlated with the depth of cell damage.For vocal folds in a pre-damage state the shear modulus values ranged from 537 Pa to 1,651 Pa (female) and from 583 Pa to 1,193 Pa (male). With increasing depth of damage from the intermediate layer of the lamina propria (LP), tissue stiffness increased consistently (compared with native values) following application of thermal damage to the vocal folds. The measurement showed an increase of tissue stiffness when the depth of tissue damage was extending from the intermediate LP layer downwards.Changes in the elastic characteristics of human vocal fold tissue following damage at defined depths were demonstrated in an in vitro experiment. In future, reproducible in vivo measurements of elastic vocal fold tissue alterations may enable phonosurgeons to infer the extent of subepithelial damage from changes in surface elasticity.

Authors with CRIS profile

Frank Roemer Institute of Radiology

Involved external institutions

Universitätsklinikum Hamburg-Eppendorf (UKE) DE Germany (DE) De Montfort University GB United Kingdom (GB)

How to cite

APA:

Rohlfs, A.-K., Schmolke, S., Clauditz, T., Hess, M., Mueller, F., Pueschel, K.,... Goodyer, E. (2017). Quantification of change in vocal fold tissue stiffness relative to depth of artificial damage. Logopedics Phoniatrics Vocology, 42(3), 108-117. https://doi.org/10.1080/14015439.2016.1221445

MLA:

Rohlfs, Anna-Katharina, et al. "Quantification of change in vocal fold tissue stiffness relative to depth of artificial damage." Logopedics Phoniatrics Vocology 42.3 (2017): 108-117.

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