Image quality, diagnostic accuracy, and potential for radiation dose reduction in thoracoabdominal CT, using Sinogram Affirmed Iterative Reconstruction (SAFIRE) technique in a longitudinal study

Journal article


Publication Details

Author(s): Scharf M, Brendel S, Melzer K, Hentschke C, May M, Uder M, Lell M
Journal: PLoS ONE
Publication year: 2017
Volume: 12
Journal issue: 7
Pages range: e0180302
ISSN: 1932-6203


Abstract


To step-wise evaluate image quality of sinogram-affirmed iterative reconstruction (SAFIRE) in reduced-dose (RD) thoracoabdominal computed tomography (CT) compared to full-dose (FD) and RD filtered back projection (FBP) in a longitudinal study.122 patients were included in this prospective study. 49 patients (14 men: mean age ± SD, 56±0.4 years; 35 women: 58±1.3 years) completed FD, RD1 (80%-dose) and RD2 (60%-dose) thoracoabdominal CT. Each CT dataset was reconstructed with FBP and SAFIRE. For quantitative image analysis image noise was measured in defined tissue regions. Qualitative image evaluation was performed according to the European Guidelines on Quality criteria for CT. Additionally artifacts, lesion conspicuity, and edge sharpness were assessed.Compared to FD-FBP noise in soft tissue increased by 12% in RD1-FBP and 27% in RD2-FBP reconstructions, whereas SAFIRE lead to a decrease of 28% (RD1) and 17% (RD2), respectively (all p <0.001). Visually sharp reproduction, lesion conspicuity, edge sharpness of pathologic findings, and overall image quality did not differ statistically significant between FD-FBP and RD-SAFIRE datasets. Image quality decreased in RD1- and RD2-FBP compared to FD-FBP, reaching statistically significance in RD2 datasets (p <0.001). In RD1- and RD2-FBP (p <0.001) streak artifacts were noted.Using SAFIRE the reference mAs in thoracoabdominal CT can be reduced by at least 30% in clinical routine without loss of image quality or diagnostic information.



FAU Authors / FAU Editors

Brendel, Stephanie
Lehrstuhl für Diagnostische Radiologie
Lehrstuhl für Sportwissenschaft mit dem Schwerpunkt Bewegung und Gesundheit
Lell, Michael Prof. Dr.
Medizinische Fakultät
May, Matthias PD Dr.
Radiologisches Institut
Uder, Michael Prof. Dr.
Lehrstuhl für Diagnostische Radiologie


How to cite

APA:
Scharf, M., Brendel, S., Melzer, K., Hentschke, C., May, M., Uder, M., & Lell, M. (2017). Image quality, diagnostic accuracy, and potential for radiation dose reduction in thoracoabdominal CT, using Sinogram Affirmed Iterative Reconstruction (SAFIRE) technique in a longitudinal study. PLoS ONE, 12(7), e0180302. https://dx.doi.org/10.1371/journal.pone.0180302

MLA:
Scharf, Michael, et al. "Image quality, diagnostic accuracy, and potential for radiation dose reduction in thoracoabdominal CT, using Sinogram Affirmed Iterative Reconstruction (SAFIRE) technique in a longitudinal study." PLoS ONE 12.7 (2017): e0180302.

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Last updated on 2018-07-10 at 03:10