Increased microcirculation detected by dynamic contrast-enhanced magnetic resonance imaging is of prognostic significance in asymptomatic myeloma
Hillengass J, Ritsch J, Merz M, Wagner B, Kunz C, Hielscher T, Laue H, Bäuerle T, Zechmann CM, Ho AD, Schlemmer HP, Goldschmidt H, Moehler TM, Delorme S (2016)
Publication Type: Journal article
Publication year: 2016
Journal
Book Volume: 174
Pages Range: 127-35
Journal Issue: 1
DOI: 10.1111/bjh.14038
Abstract
This prospective study aimed to investigate the prognostic significance of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) as a non-invasive imaging technique delivering the quantitative parameters amplitude A (reflecting blood volume) and exchange rate constant kep (reflecting vascular permeability) in patients with asymptomatic monoclonal plasma cell diseases. We analysed DCE-MRI parameters in 33 healthy controls and 148 patients with monoclonal gammopathy of undetermined significance (MGUS) or smouldering multiple myeloma (SMM) according to the 2003 IMWG guidelines. All individuals underwent standardized DCE-MRI of the lumbar spine. Regions of interest were drawn manually on T1-weighted images encompassing the bone marrow of each of the 5 lumbar vertebrae sparing the vertebral vessel. Prognostic significance for median of amplitude A (univariate: P < 0·001, hazard ratio (HR) 2·42, multivariate P = 0·02, HR 2·7) and exchange rate constant kep (univariate P = 0·03, HR 1·92, multivariate P = 0·46, HR 1·5) for time to progression of 79 patients with SMM was found. Patients with amplitude A above the optimal cut-off point of 0·89 arbitrary units had a 2-year progression rate into symptomatic disease of 80%. In conclusion, DCE-MRI parameters are of prognostic significance for time to progression in patients with SMM but not in individuals with MGUS.
Authors with CRIS profile
Involved external institutions
Universitätsklinikum Heidelberg
Germany (DE)
Deutsches Krebsforschungszentrum (DKFZ)
Germany (DE)
InVentiv Health Clinical
Germany (DE)
Ruprecht-Karls-Universität Heidelberg
Germany (DE)
Fraunhofer-Institut für Bildgestützte Medizin (MEVIS)
Germany (DE)
Germany (DE)
Deutsches Krebsforschungszentrum (DKFZ)
Germany (DE)
InVentiv Health Clinical
Germany (DE)
Ruprecht-Karls-Universität Heidelberg
Germany (DE)
Fraunhofer-Institut für Bildgestützte Medizin (MEVIS)
Germany (DE)
How to cite
APA:
Hillengass, J., Ritsch, J., Merz, M., Wagner, B., Kunz, C., Hielscher, T.,... Delorme, S. (2016). Increased microcirculation detected by dynamic contrast-enhanced magnetic resonance imaging is of prognostic significance in asymptomatic myeloma. British Journal of Haematology, 174(1), 127-35. https://doi.org/10.1111/bjh.14038
MLA:
Hillengass, Jens, et al. "Increased microcirculation detected by dynamic contrast-enhanced magnetic resonance imaging is of prognostic significance in asymptomatic myeloma." British Journal of Haematology 174.1 (2016): 127-35.
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