Optimization of the mechanical properties of calcium phosphate/multi-walled carbon nanotubes/bovine serum albumin composites using response surface methodology

Journal article


Publication Details

Author(s): Low KL, Tan SH, Zein SHS, Mcphail DS, Boccaccini AR
Journal: Materials and Design
Publisher: Elsevier BV
Publication year: 2011
Journal issue: 32
Pages range: 3312-3319
ISSN: 0264-1275


Abstract


Response surface methodology (RSM) coupled with the central composite design (CCD) was used to optimize the mechanical properties of calcium phosphate cement/multi-walled carbon nanotubes/bovine serum albumin (CPC/MWCNTs/BSA) composites. In this study, CPC composites were reinforced by multi-walled carbon nanotubes (MWCNTs) and bovine serum albumin (BSA) in order to induce high mechanical properties in the CPC/MWCNTs/BSA system. The effect of various process parameters on the compressive strength of CPC/MWCNTs/BSA composites was studied using design of experiments (DOE). The process parameters studied were: wt.% of MWCNTs (0.2-0.5 wt.%), wt.% of BSA (5-15. wt.%) and type of MWCNTs (e.g. as-pristine MWCNT (MWCNT-AP), hydroxyl group functionalized MWCNT (MWCNT-OH) and carboxyl group functionalized MWCNT (MWCNT-COOH)). Based on the CCD, a quadratic model was obtained to correlate the process parameters to the compressive strength of CPC/MWCNTs/BSA composites. From the analysis of variance (ANOVA), the most significant factor affected on the experimental design response was identified. The predicted compressive strength after process optimization was found to agree well with the experimental value. The results revealed that at 0.5. wt.% of MWCNT-OH and 15. wt.% of BSA, the highest compressive strength of 14. MPa was obtained. © 2011 Elsevier Ltd.



FAU Authors / FAU Editors

Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)


External institutions with authors

Imperial College London / The Imperial College of Science, Technology and Medicine
University of Science Malaysia (USM) / Universiti Sains Malaysia


How to cite

APA:
Low, K.L., Tan, S.H., Zein, S.H.S., Mcphail, D.S., & Boccaccini, A.R. (2011). Optimization of the mechanical properties of calcium phosphate/multi-walled carbon nanotubes/bovine serum albumin composites using response surface methodology. Materials and Design, 32, 3312-3319. https://dx.doi.org/10.1016/j.matdes.2011.02.022

MLA:
Low, Kah Ling, et al. "Optimization of the mechanical properties of calcium phosphate/multi-walled carbon nanotubes/bovine serum albumin composites using response surface methodology." Materials and Design 32 (2011): 3312-3319.

BibTeX: 

Last updated on 2018-07-08 at 03:57