Vascular Tissue Engineering: Effects of Integrating Collagen into a PCL Based Nanofiber Material

Journal article

Publication Details

Author(s): Bertram U, Steiner D, Poppitz B, Dippold D, Köhn K, Beier J, Detsch R, Boccaccini AR, Schubert DW, Horch RE, Arkudas A
Journal: BioMed Research International
Publisher: HINDAWI LTD
Publication year: 2017
Volume: 2017
Pages range: 1-11
ISSN: 2314-6133


The engineering of vascular grafts is a growing field in regenerative medicine. Although numerous attempts have been made, the current vascular grafts made of polyurethane (PU), Dacron (R), or Teflon (R) still display unsatisfying results. Electrospinning of biopolymers and native proteins has been in the focus of research to imitate the extracellular matrix (ECM) of vessels to produce a small caliber, off-the-shelf tissue engineered vascular graft (TEVG) as a substitute for poorly performing PU, Dacron, or Teflon prostheses. Blended poly-epsilon-caprolactone (PCL)/collagen grafts have shown promising results regarding biomechanical and cell supporting features. In order to find a suitable PCL/collagen blend, we fabricated plane electrospun PCL scaffolds using various collagen type I concentrations ranging from 5% to 75%. We analyzed biocompatibility and morphological aspects in vitro. Our results show beneficial features of collagen I integration regarding cell viability and functionality, but also adverse effects like the loss of a confluent monolayer at high concentrations of collagen. Furthermore, electrospun PCL scaffolds containing 25% collagen I seem to be ideal for engineering vascular grafts.

FAU Authors / FAU Editors

Arkudas, Andreas Prof. Dr.
Medizinische Fakultät
Bertram, Ulf
Plastisch- und Handchirurgische Klinik
Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Detsch, Rainer Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Dippold, Dirk
Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe)
Horch, Raymund E. Prof. Dr.
Professur für Plastische Chirurgie und Handchirurgie
Köhn, Katrin
Plastisch- und Handchirurgische Klinik
Schubert, Dirk W. Prof. Dr.
Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe)
Steiner, Dominik Dr. med.
Plastisch- und Handchirurgische Klinik

How to cite

Bertram, U., Steiner, D., Poppitz, B., Dippold, D., Köhn, K., Beier, J.,... Arkudas, A. (2017). Vascular Tissue Engineering: Effects of Integrating Collagen into a PCL Based Nanofiber Material. BioMed Research International, 2017, 1-11.

Bertram, Ulf, et al. "Vascular Tissue Engineering: Effects of Integrating Collagen into a PCL Based Nanofiber Material." BioMed Research International 2017 (2017): 1-11.


Last updated on 2019-02-04 at 08:53