Fabrication and characterization of electrospun poly-DL-lactide (PDLLA) fibrous coatings on 45S5 Bioglass® substrates for bone tissue engineering applications
Yunos DM, Ahmad Z, Boccaccini AR (2010)
Publication Type: Journal article
Publication year: 2010
Journal
Publisher: Wiley-Blackwell
Book Volume: 85
Pages Range: 768-774
DOI: 10.1002/jctb.2283
Abstract
BACKGROUND: This work focuses on combining electrospun biodegradable poly-DL-lactide (PDLLA) fibres and 45S5 Bioglass® for tissue engineering applications. RESULTS: A variety of fibrous structures were produced upon application of an electric field to a flowing solution of PDLLA (5 wt/v%) in di-methyl carbonate (DMC). Electrospinning was achieved at an applied voltage of 8.5 kV for a fixed flow rate of 5 μ Lmin-1. Scanning electron microscopy images of PDLLA fibres deposited on 45S5 Bioglass® sintered pellets revealed that the fibres had diameters in the range 100-200 nm, leading to increased surface roughness, as assessed by white light interferometry. Bioactivity studies on PDLLA fibre coated Bioglass® substrates were carried out in simulated body fluid (SBF) for 7, 14 and 28 days. It was found that mineralization of PDLLA fibres on 45S5 Bioglass® substrate (formation of hydroxyapatite) occurred after 7 days of immersion in SBF and full coverage of PDLLA fibres with HA nanocrystals was achieved after 14 days in SBF. CONCLUSION: The approach investigated represents a convenient method to develop a controlled mineralized fibrous topography on bioactive glass substrates for improved cell attachment, which can be exploited in bone tissue engineering applications. ©2009 Society of Chemical Industry.
Authors with CRIS profile
Involved external institutions
University College London (UCL)
United Kingdom (GB)
Imperial College London / The Imperial College of Science, Technology and Medicine
United Kingdom (GB)
United Kingdom (GB)
Imperial College London / The Imperial College of Science, Technology and Medicine
United Kingdom (GB)
How to cite
APA:
Yunos, D.M., Ahmad, Z., & Boccaccini, A.R. (2010). Fabrication and characterization of electrospun poly-DL-lactide (PDLLA) fibrous coatings on 45S5 Bioglass® substrates for bone tissue engineering applications. Journal of Chemical Technology and Biotechnology, 85, 768-774. https://doi.org/10.1002/jctb.2283
MLA:
Yunos, D. M., Z. Ahmad, and Aldo R. Boccaccini. "Fabrication and characterization of electrospun poly-DL-lactide (PDLLA) fibrous coatings on 45S5 Bioglass® substrates for bone tissue engineering applications." Journal of Chemical Technology and Biotechnology 85 (2010): 768-774.
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