Daytime systolic ambulatory blood pressure with a two-step switch from candesartan to olmesartan monotherapy and the fixed-dose combination of olmesartan/amlodipine in patients with uncontrolled essential hypertension (SEVICONTROL-2)

Bramlage P, Zemmrich C, Gansz A, Sturm CD, Fimmers R, Nadal J, Schmieder R, Schrader J, Lueders S (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Journal of Clinical Hypertension Wiley-Blackwell

Book Volume: 16

Pages Range: 41-6

Journal Issue: 1

DOI: 10.1111/jch.12227

Abstract

The objective of this study was to investigate the efficacy of the fixed-dose combination olmesartan/amlodipine 40/10 mg in patients with moderate essential hypertension not controlled on candesartan 32 mg. This was a prospective, single-arm, phase IV study. The primary endpoint was the change in mean daytime systolic blood pressure (BP). A total of 77 of 89 screened patients started candesartan 32 mg, 62 olmesartan 40 mg, and 57 olmesartan 40 mg/amlodipine 10 mg. Mean daytime systolic BP was reduced by 9.8±15.2 mm Hg (P<.001) vs candesartan monotherapy. Office BP reduction was 9.2±18.8/5.0±8.9 mm Hg (P<0.001). Treatment goals (<140/90 mm Hg for office and <135/85 mm Hg for ambulatory BP) were achieved in 58.2% and 78.4% of patients, respectively. There was one drug-related adverse event (edema) and no serious adverse events. Patients of Caucasian ethnicity with moderate essential hypertension uncontrolled on candesartan experienced a further drop in BP using olmesartan and amlodipine.

Authors with CRIS profile

Roland Schmieder Professur für Innere Medizin (Nephrologie)

Involved external institutions

St. Josefs-Hospital Wiesbaden DE Germany (DE) Universitätsklinikum Bonn DE Germany (DE)

How to cite

APA:

Bramlage, P., Zemmrich, C., Gansz, A., Sturm, C.-D., Fimmers, R., Nadal, J.,... Lueders, S. (2014). Daytime systolic ambulatory blood pressure with a two-step switch from candesartan to olmesartan monotherapy and the fixed-dose combination of olmesartan/amlodipine in patients with uncontrolled essential hypertension (SEVICONTROL-2). Journal of Clinical Hypertension, 16(1), 41-6. https://doi.org/10.1111/jch.12227

MLA:

Bramlage, Peter, et al. "Daytime systolic ambulatory blood pressure with a two-step switch from candesartan to olmesartan monotherapy and the fixed-dose combination of olmesartan/amlodipine in patients with uncontrolled essential hypertension (SEVICONTROL-2)." Journal of Clinical Hypertension 16.1 (2014): 41-6.

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