Incorporation of vitamin E in poly(3hydroxybutyrate)/Bioglass composite films: effect on surface properties and cell attachment

Misra SK, Philip SE, Chrzanowski W, Nazhat SN, Roy I, Knowles JC, Salih V, Boccaccini AR (2009)

Publication Type: Journal article

Publication year: 2009

Journal

Journal of the Royal Society Interface Royal Society, The

Publisher: Royal Society, The

Pages Range: 401-409

Journal Issue: 6

DOI: 10.1098/rsif.2008.0278

Abstract

This study investigated the possibility of incorporating α-tocopherol (vitamin E) into poly(3hydroxybutyrate) (P(3HB))/Bioglass composites, which are being developed for bone tissue engineering matrices. P(3HB) films with 20 wt% Bioglass and 10 wt% vitamin E were prepared using the solvent casting technique. Addition of vitamin E significantly improved the hydrophilicity of the composites along with increasing the total protein adsorption. The presence of protein adsorbed on the composite surface was further confirmed using X-ray photoelectron spectroscopy analysis. Preliminary cell culture studies using MG-63 human osteoblasts showed that the addition of vitamin E in the P(3HB)/20 wt% Bioglass films significantly increased cell proliferation. The results achieved in this study confirmed the possibility of incorporating vitamin E as a suitable additive in P(3HB)/Bioglass composites to engineer the surface of the composites by promoting higher protein adsorption and increasing the hydrophilicity. © 2008 The Royal Society.

Authors with CRIS profile

Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Imperial College London / The Imperial College of Science, Technology and Medicine GB United Kingdom (GB) University of Westminster GB United Kingdom (GB) University College London (UCL) GB United Kingdom (GB) McGill University CA Canada (CA)

How to cite

APA:

Misra, S.K., Philip, S.E., Chrzanowski, W., Nazhat, S.N., Roy, I., Knowles, J.C.,... Boccaccini, A.R. (2009). Incorporation of vitamin E in poly(3hydroxybutyrate)/Bioglass composite films: effect on surface properties and cell attachment. Journal of the Royal Society Interface, 6, 401-409. https://doi.org/10.1098/rsif.2008.0278

MLA:

Misra, Superb K., et al. "Incorporation of vitamin E in poly(3hydroxybutyrate)/Bioglass composite films: effect on surface properties and cell attachment." Journal of the Royal Society Interface 6 (2009): 401-409.

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