3 Tesla (23)Na Magnetic Resonance Imaging During Acute Kidney Injury

Hammon M, Großmann S, Linz P, Seuss H, Hammon R, Rosenhauer D, Janka RM, Luft FC, Titze J, Uder M, Dahlmann A, Cavallaro AJ (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Book Volume: 24

Pages Range: 1086-1093

Journal Issue: 9

DOI: 10.1016/j.acra.2017.03.012

Abstract

Sodium and proton magnetic resonance imaging ((23)Na/(1)H-MRI) have shown that muscle and skin can store Na(+) without water. In chronic renal failure and in heart failure, Na(+) mobilization occurs, but is variable depending on age, dialysis vintage, and other features. Na(+) storage depots have not been studied in patients with acute kidney injury (AKI).We studied 7 patients with AKI (mean age: 51.7 years; range: 25-84) and 14 age-matched and gender-matched healthy controls. All underwent (23)Na/(1)H-MRI at the calf. Patients were studied before and after acute hemodialysis therapy within 5-6 days. The (23)Na-MRI produced grayscale images containing Na(+) phantoms, which served to quantify Na(+) contents. A fat-suppressed inversion recovery sequence was used to quantify H2O content.Plasma Na(+) levels did not change. Mean Na(+) contents in muscle and skin did not significantly change following four to five cycles of hemodialysis treatment (before therapy: 32.7 ± 6.9 and 44.2 ± 13.5 mmol/L, respectively; after dialysis: 31.7 ± 10.2 and 42.8 ± 11.8 mmol/L, respectively; P > .05). Water content measurements did not differ significantly before and after hemodialysis in muscle and skin (P > .05). Na(+) contents in calf muscle and skin of patients before hemodialysis were significantly higher than in healthy subjects (16.6 ± 2.1 and 17.9 ± 3.2) and remained significantly elevated after hemodialysis.Na(+) in muscle and skin accumulates in patients with AKI and, in contrast to patients receiving chronic hemodialysis and those with acute heart failure, is not mobilized with hemodialysis within 5-6 days.

Authors with CRIS profile

Involved external institutions

Vanderbilt University United States (USA) (US) Klinikum Nürnberg Germany (DE) Max-Delbrück-Centrum für Molekulare Medizin / Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch Germany (DE)

How to cite

APA:

Hammon, M., Großmann, S., Linz, P., Seuss, H., Hammon, R., Rosenhauer, D.,... Cavallaro, A.J. (2017). 3 Tesla (23)Na Magnetic Resonance Imaging During Acute Kidney Injury. Academic Radiology, 24(9), 1086-1093. https://dx.doi.org/10.1016/j.acra.2017.03.012

MLA:

Hammon, Matthias, et al. "3 Tesla (23)Na Magnetic Resonance Imaging During Acute Kidney Injury." Academic Radiology 24.9 (2017): 1086-1093.

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