Biermann M, Griffante G, Podolska M, Boeltz S, Stürmer J, Munoz LE, Bilyy R, Herrmann M, Munoz Becerra L (2016)
Publication Type: Journal article
Publication year: 2016
Book Volume: 25
Pages Range: 934-42
Journal Issue: 8
Glycosylation is well-known to modulate the functional capabilities of immunoglobulin G (IgG)-mediated cellular and humoral responses. Indeed, highly sialylated and desialylated IgG is endowed with anti- and pro-inflammatory activities, respectively, whereas fully deglycosylated IgG is a rather lame duck, with no effector function besides toxin neutralization. Recently, several studies revealed the impact of different glycosylation patterns on the Fc part and Fab fragment of IgG in several autoimmune diseases, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Here, we provide a synoptic update summarizing the most important aspects of antibody glycosylation, and the current progress in this field. We also discuss the therapeutic options generated by the modification of the glycosylation of IgG in a potential treatment for chronic inflammatory diseases.
APA:
Biermann, M., Griffante, G., Podolska, M., Boeltz, S., Stürmer, J., Munoz, L.E.,... Munoz Becerra, L. (2016). Sweet but dangerous - the role of immunoglobulin G glycosylation in autoimmunity and inflammation. Lupus, 25(8), 934-42. https://dx.doi.org/10.1177/0961203316640368
MLA:
Biermann, Mona, et al. "Sweet but dangerous - the role of immunoglobulin G glycosylation in autoimmunity and inflammation." Lupus 25.8 (2016): 934-42.
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