Development of a Dual-Energy Computed Tomography Scoring System for Measurement of Urate Deposition in Gout

Journal article


Publication Details

Author(s): Bayat S, Aati O, Rech J, Sapsford M, Cavallaro A, Lell M, Araujo E, Petsch C, Stamp LK, Schett G, Manger B, Dalbeth N
Journal: Arthritis & Rheumatism-Arthritis Care & Research
Publication year: 2016
Volume: 68
Journal issue: 6
Pages range: 769-75
ISSN: 2151-464X


Abstract


To develop a semiquantitative dual-energy computed tomography (DECT) scoring system for measurement of urate deposition in gout.Following a structured review of images, a semiquantitative DECT urate scoring method for foot/ankle scans was developed for testing. This method included 4 regions, each scored 0-3, with a maximum total DECT urate score of 12. DECT scans from 224 patients (182 with gout, 42 without gout) were scored by 2 independent readers. Automated urate volumes were also measured. Paired scans from 8 patients receiving pegloticase were analyzed, and a timing exercise was undertaken. The properties of the DECT urate score were analyzed according to the Outcome Measures in Rheumatology (OMERACT) filter.The interreader intraclass correlation coefficient (95% confidence interval) for the DECT urate score was 0.98 (0.97-0.98). All scored regions contributed to the total DECT urate score. DECT urate scores and volumes were highly correlated (r = 0.91, P < 0.0001). Both DECT urate scores and volumes discriminated between gout and nongout control participants and between the tophaceous gout, nontophaceous gout, and control groups. Compared with urate volume, the DECT urate score had greater ability to discriminate between responders and nonresponders to pegloticase therapy (P < 0.001 for DECT urate score and P > 0.05 for volume). The mean ± SD time required for the DECT urate score was 121 ± 2 seconds and for urate volume was 240 ± 2 seconds (P = 2 × 10(-31) ).We have developed a novel semiquantitative DECT scoring method for measurement of urate deposition in the feet/ankles. This method fulfills many aspects of the OMERACT filter.



FAU Authors / FAU Editors

Lell, Michael Prof. Dr.
Medizinische Fakultät
Manger, Bernhard Prof. Dr. med.
Professur für Rheumatologie und Klinische Immunologie
Petsch, Christina
Lehrstuhl für Innere Medizin III
Schett, Georg Prof. Dr. med.
Lehrstuhl für Innere Medizin III


External institutions with authors

University of Auckland
University of Otago


How to cite

APA:
Bayat, S., Aati, O., Rech, J., Sapsford, M., Cavallaro, A., Lell, M.,... Dalbeth, N. (2016). Development of a Dual-Energy Computed Tomography Scoring System for Measurement of Urate Deposition in Gout. Arthritis & Rheumatism-Arthritis Care & Research, 68(6), 769-75. https://dx.doi.org/10.1002/acr.22754

MLA:
Bayat, Sara, et al. "Development of a Dual-Energy Computed Tomography Scoring System for Measurement of Urate Deposition in Gout." Arthritis & Rheumatism-Arthritis Care & Research 68.6 (2016): 769-75.

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Last updated on 2018-07-10 at 02:43