Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Hedegaard J, Lamy P, Nordentoft I, Algaba F, Hoyer S, Ulhoi BP, Vang S, Reinert T, Hermann GG, Mogensen K, Thomsen MBH, Nielsen MM, Marquez M, Segersten U, Aine M, Hoglund M, Birkenkamp-Demtroder K, Fristrup N, Borre M, Hartmann A, Stoehr R, Wach S, Keck B, Seitz AK, Nawroth R, Maurer T, Tulic C, Simic T, Junker K, Horstmann M, Harving N, Petersen AC, Luz Calle M, Steyerberg EW, Beukers W, Van Kessel KEM, Jensen JB, Pedersen JS, Malmstrom PU, Malats N, Real FX, Zwarthoff EC, Orntoft TF, Dyrskjot L
Zeitschrift: Cancer Cell
Jahr der Veröffentlichung: 2016
Band: 30
Heftnummer: 1
Seitenbereich: 27-42
ISSN: 1535-6108


Abstract


Non-muscle-invasive bladder cancer (NMIBC) is a heterogeneous disease with widely different outcomes. We performed a comprehensive transcriptional analysis of 460 early-stage urothelial carcinomas and showed that NMIBC can be subgrouped into three major classes with basal- and luminal-like characteristics and different clinical outcomes. Large differences in biological processes such as the cell cycle, epithelial-mesenchymal transition, and differentiation were observed. Analysis of transcript variants revealed frequent mutations in genes encoding proteins involved in chromatin organization and cytoskeletal functions. Furthermore, mutations in well-known cancer driver genes (e.g., TP53 and ERBB2) were primarily found in high-risk tumors, together with APOBEC-related mutational signatures. The identification of subclasses in NMIBC may offer better prognostication and treatment selection based on subclass assignment.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Hartmann, Arndt Prof. Dr. med.
Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie
Keck, Bastian PD Dr.
Medizinische Fakultät


Einrichtungen weiterer Autorinnen und Autoren

Aalborg University
Aarhus University Hospital / Aarhus Universitetshospital
Autonomous University of Barcelona (UAB) / Universitat Autònoma de Barcelona
Erasmus University Medical Center
Frederiksberg Hospital
Friedrich-Schiller-Universität Jena
Lund University / Lunds universitet
Spanish National Cancer Research Centre / Centro Nacional de Investigaciones Oncológicas (CNIO)
Technische Universität München (TUM)
Universität des Saarlandes (UdS)
University of Belgrade / Универзитет у Београду
University of Vic - Central University of Catalonia (UVic-UCC)
Uppsala University


Zitierweisen

APA:
Hedegaard, J., Lamy, P., Nordentoft, I., Algaba, F., Hoyer, S., Ulhoi, B.P.,... Dyrskjot, L. (2016). Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma. Cancer Cell, 30(1), 27-42. https://dx.doi.org/10.1016/j.ccell.2016.05.004

MLA:
Hedegaard, Jakob, et al. "Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma." Cancer Cell 30.1 (2016): 27-42.

BibTeX: 

Zuletzt aktualisiert 2018-07-10 um 02:42