Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma

Hedegaard J, Lamy P, Nordentoft I, Algaba F, Hoyer S, Ulhoi BP, Vang S, Reinert T, Hermann GG, Mogensen K, Thomsen MBH, Nielsen MM, Marquez M, Segersten U, Aine M, Hoglund M, Birkenkamp-Demtroder K, Fristrup N, Borre M, Hartmann A, Stoehr R, Wach S, Keck B, Seitz AK, Nawroth R, Maurer T, Tulic C, Simic T, Junker K, Horstmann M, Harving N, Petersen AC, Luz Calle M, Steyerberg EW, Beukers W, Van Kessel KEM, Jensen JB, Pedersen JS, Malmstrom PU, Malats N, Real FX, Zwarthoff EC, Orntoft TF, Dyrskjot L (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Cancer Cell Elsevier (Cell Press)

Book Volume: 30

Pages Range: 27-42

Journal Issue: 1

DOI: 10.1016/j.ccell.2016.05.004

Abstract

Non-muscle-invasive bladder cancer (NMIBC) is a heterogeneous disease with widely different outcomes. We performed a comprehensive transcriptional analysis of 460 early-stage urothelial carcinomas and showed that NMIBC can be subgrouped into three major classes with basal- and luminal-like characteristics and different clinical outcomes. Large differences in biological processes such as the cell cycle, epithelial-mesenchymal transition, and differentiation were observed. Analysis of transcript variants revealed frequent mutations in genes encoding proteins involved in chromatin organization and cytoskeletal functions. Furthermore, mutations in well-known cancer driver genes (e.g., TP53 and ERBB2) were primarily found in high-risk tumors, together with APOBEC-related mutational signatures. The identification of subclasses in NMIBC may offer better prognostication and treatment selection based on subclass assignment.

Authors with CRIS profile

Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Bastian Keck Medizinische Fakultät

Involved external institutions

Technische Universität München (TUM) DE Germany (DE) University of Belgrade / Универзитет у Београду RS Serbia (RS) Universität des Saarlandes (UdS) DE Germany (DE) Friedrich-Schiller-Universität Jena DE Germany (DE) Aalborg University DK Denmark (DK) University of Vic - Central University of Catalonia (UVic-UCC) ES Spain (ES) Erasmus University Medical Center (MC) NL Netherlands (NL) Aarhus University Hospital / Aarhus Universitetshospital DK Denmark (DK) Uppsala University SE Sweden (SE) Spanish National Cancer Research Centre / Centro Nacional de Investigaciones Oncológicas (CNIO) ES Spain (ES) Lund University / Lunds universitet SE Sweden (SE) Autonomous University of Barcelona (UAB) / Universitat Autònoma de Barcelona ES Spain (ES) Frederiksberg Hospital DK Denmark (DK)

How to cite

APA:

Hedegaard, J., Lamy, P., Nordentoft, I., Algaba, F., Hoyer, S., Ulhoi, B.P.,... Dyrskjot, L. (2016). Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma. Cancer Cell, 30(1), 27-42. https://doi.org/10.1016/j.ccell.2016.05.004

MLA:

Hedegaard, Jakob, et al. "Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma." Cancer Cell 30.1 (2016): 27-42.

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