Fate of the glucose degradation products 3-deoxyglucosone and glyoxal during peritoneal dialysis

Journal article


Publication Details

Author(s): Tauer A, Bender T, Fleischmann E, Niwa T, Jörres A, Pischetsrieder M
Journal: Molecular Nutrition & Food Research
Publisher: Wiley-VCH Verlag
Publication year: 2005
Volume: 49
Pages range: 710-715
ISSN: 1613-4125


Abstract


Conventional fluids for peritoneal dialysis (PD) contain reactive glucose degradation products (GDPs) as a result of glucose breakdown during heat-sterilization. GDPs in PD fluids (PDFs) have been associated with the progressive alteration of the peritoneal membrane during long-term PD by cytotoxic effects and formation of advanced glycation endproducts (AGEs). In this study, we investigated the possible fate of two characteristic GDPs, 3-deoxyglucosone (3-DG) and glyoxal, during PD. In vivo, 3-DG and glyoxal concentrations, which were analyzed by high-performance liquid chromatography (HPLC), decreased in PDFs by 78% and 88% during 4 h of dwell time. The PDFs were then incubated in vitro in the presence of the most important reaction partners of GDPs in the peritoneal cavity. Neither human peritoneal mesothelial cells, human peritoneal fibroblasts, soluble protein, an insoluble collagen surface, nor components of spent dialysate led to a significant reduction of 3-DG or glyoxal after 6 h. Only after long-term incubation, a noticeable decrease of 3-DG was observed (-37% after three weeks), more likely due to spontaneous degradation reaction than formation of advanced glycation endproducts. These results suggest that in the course of PD, 3-DG, and glyoxal are absorbed into the organism and thus might contribute to the systemic pool of reactive carbonyl compounds. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.



FAU Authors / FAU Editors

Pischetsrieder, Monika Prof. Dr.
Lehrstuhl für Lebensmittelchemie (Henriette-Schmidt-Burkhardt Lehrstuhl)


Additional Organisation
Emil-Fischer-Zentrum (Emil Fischer Center)


How to cite

APA:
Tauer, A., Bender, T., Fleischmann, E., Niwa, T., Jörres, A., & Pischetsrieder, M. (2005). Fate of the glucose degradation products 3-deoxyglucosone and glyoxal during peritoneal dialysis. Molecular Nutrition & Food Research, 49, 710-715. https://dx.doi.org/10.1002/mnfr.200400111

MLA:
Tauer, Andreas, et al. "Fate of the glucose degradation products 3-deoxyglucosone and glyoxal during peritoneal dialysis." Molecular Nutrition & Food Research 49 (2005): 710-715.

BibTeX: 

Last updated on 2018-30-06 at 02:23