Long-term patient survival and kidney allograft survival in post-transplant diabetes mellitus: a single-center retrospective study

Dienemann T, Fujii N, Li Y, Govani S, Kosaraju N, Bloom RD, Feldman HI (2016)


Publication Type: Journal article

Publication year: 2016

Journal

Book Volume: 29

Pages Range: 1017-28

Journal Issue: 9

DOI: 10.1111/tri.12807

Abstract

A decade ago, observations suggested that post-transplant diabetes mellitus (PTDM) was linked to allograft loss and shorter patient survival. Increasing awareness, improvements in care, and changes in the immunosuppressive regimen may have modified this association. Single-center analysis of 1990 (age>18; transplantation date 1996-2012) primary kidney recipients (KTR). Patients with <12 months follow-up were excluded. Diabetes was diagnosed according to ADA criteria and characterized as follows: No diabetes, PTDM in the first post-transplant year not treated with glucose-lowering medications (GLM) at 12 months, PTDM in the first post-transplant year treated with GLM at 12 months, and pretransplant diabetes. Cox proportional hazards models were used to examine the relationship of PTDM with allograft and patient survival. Mean follow-up time was 6.8 years for allograft survival and 7.4 years for patient survival. PTDM treated with medication at year one was not associated with allograft survival (HR 1.28, 95% CI 0.97-1.69), but was significantly associated with overall mortality and death with functioning graft (DWFG) (HR overall: 1.81, 95% CI 1.36-2.39; HR DWFG: 1.59 95% CI 1.05-2.38). In this cohort, KTR with PTDM being treated with glucose-lowering medication at 12 months experienced significantly shorter overall survival and survival with functioning graft.

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How to cite

APA:

Dienemann, T., Fujii, N., Li, Y., Govani, S., Kosaraju, N., Bloom, R.D., & Feldman, H.I. (2016). Long-term patient survival and kidney allograft survival in post-transplant diabetes mellitus: a single-center retrospective study. Transplant International, 29(9), 1017-28. https://dx.doi.org/10.1111/tri.12807

MLA:

Dienemann, Thomas, et al. "Long-term patient survival and kidney allograft survival in post-transplant diabetes mellitus: a single-center retrospective study." Transplant International 29.9 (2016): 1017-28.

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