Rhinovirus inhibits IL-17A and the downstream immune responses in allergic asthma

Journal article


Publication Details

Author(s): Graser A, Ekici AB, Sopel N, Melichar VO, Zimmermann T, Papadopoulos NG, Taka S, Ferrazzi F, Vuorinen T, Finotto S
Journal: Mucosal Immunology
Publication year: 2016
Volume: 9
Journal issue: 5
Pages range: 1183-92
ISSN: 1933-0219


Abstract


The proinflammatory cytokine interleukin-17A (IL-17A) is known to mediate antimicrobial activity, but its role during rhinovirus (RV) infections and in asthma needs further investigation. Therefore, we addressed the role of IL-17A during allergic asthma and antiviral immune response in human and murine immunocompetent cells. In this study we found that asthmatic children with a RV infection in their upper airways have upregulated mRNA levels of the antiviral cytokine interferon type I (IFN)-? and the transcription factor T-box 21 (TBX21) and reduced levels of IL-17A protein in their peripheral blood mononuclear cells (PBMCs). We also found that IL-17A inhibited RV1b replication in infected human lung epithelial cells A549. Furthermore, by using gene array analysis we discovered that targeted deletion of Il17a in murine lung CD4(+) T cells impaired Oas1g mRNA downstream of Ifn?, independently from RV infection. Additionally, in PBMCs of children with a RV infection in their nasalpharyngeal fluid OAS1 gene expression was found downregulated. Finally RV1b inhibited IL-17A production in lung CD4(+) T cells in a setting of experimental asthma. These results indicate that the RV1b inhibits IL-17A in T helper type 17 cells and IL-17A clears RV1b infection in epithelial cells. In both cases IL-17A contributes to fend off RV1b infection by inducing genes downstream of interferon type I pathway.



FAU Authors / FAU Editors

Ekici, Arif Bülent Dr. rer. nat.
Humangenetisches Institut
Ferrazzi, Fulvia Dr.
Humangenetisches Institut
Graser, Anna Dr. rer. nat.
Molekular-Pneumologische Abteilung
Sopel, Nina Dr. rer. nat.
Molekular-Pneumologische Abteilung
Zimmermann, Theodor apl. Prof. Dr.
Medizinische Fakultät


External institutions with authors

National and Kapodistrian University of Athens
University of Turku / Turun yliopisto


How to cite

APA:
Graser, A., Ekici, A.B., Sopel, N., Melichar, V.O., Zimmermann, T., Papadopoulos, N.G.,... Finotto, S. (2016). Rhinovirus inhibits IL-17A and the downstream immune responses in allergic asthma. Mucosal Immunology, 9(5), 1183-92. https://dx.doi.org/10.1038/mi.2015.130

MLA:
Graser, Anna, et al. "Rhinovirus inhibits IL-17A and the downstream immune responses in allergic asthma." Mucosal Immunology 9.5 (2016): 1183-92.

BibTeX: 

Last updated on 2018-07-10 at 02:34