Rhinovirus inhibits IL-17A and the downstream immune responses in allergic asthma

Graser A, Ekici AB, Sopel N, Melichar VO, Zimmermann T, Papadopoulos NG, Taka S, Ferrazzi F, Vuorinen T, Finotto S (2016)


Publication Type: Journal article

Publication year: 2016

Journal

Book Volume: 9

Pages Range: 1183-92

Journal Issue: 5

DOI: 10.1038/mi.2015.130

Abstract

The proinflammatory cytokine interleukin-17A (IL-17A) is known to mediate antimicrobial activity, but its role during rhinovirus (RV) infections and in asthma needs further investigation. Therefore, we addressed the role of IL-17A during allergic asthma and antiviral immune response in human and murine immunocompetent cells. In this study we found that asthmatic children with a RV infection in their upper airways have upregulated mRNA levels of the antiviral cytokine interferon type I (IFN)-? and the transcription factor T-box 21 (TBX21) and reduced levels of IL-17A protein in their peripheral blood mononuclear cells (PBMCs). We also found that IL-17A inhibited RV1b replication in infected human lung epithelial cells A549. Furthermore, by using gene array analysis we discovered that targeted deletion of Il17a in murine lung CD4(+) T cells impaired Oas1g mRNA downstream of Ifn?, independently from RV infection. Additionally, in PBMCs of children with a RV infection in their nasalpharyngeal fluid OAS1 gene expression was found downregulated. Finally RV1b inhibited IL-17A production in lung CD4(+) T cells in a setting of experimental asthma. These results indicate that the RV1b inhibits IL-17A in T helper type 17 cells and IL-17A clears RV1b infection in epithelial cells. In both cases IL-17A contributes to fend off RV1b infection by inducing genes downstream of interferon type I pathway.

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APA:

Graser, A., Ekici, A.B., Sopel, N., Melichar, V.O., Zimmermann, T., Papadopoulos, N.G.,... Finotto, S. (2016). Rhinovirus inhibits IL-17A and the downstream immune responses in allergic asthma. Mucosal Immunology, 9(5), 1183-92. https://dx.doi.org/10.1038/mi.2015.130

MLA:

Graser, Anna, et al. "Rhinovirus inhibits IL-17A and the downstream immune responses in allergic asthma." Mucosal Immunology 9.5 (2016): 1183-92.

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