FLAIRfusion Processing with Contrast Inversion : Improving Detection and Reading Time of New Cerebral MS Lesions

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Schmidt M, Linker R, Lang S, Lücking H, Engelhorn T, Kloska S, Uder M, Cavallaro A, Dörfler A, Dankerl P
Zeitschrift: Clinical Neuroradiology
Jahr der Veröffentlichung: 2017
ISSN: 1869-1439


Abstract


To evaluate the performance of an innovative image processing approach for detection of T2-weighted hyperintense multiple sclerosis (MS) lesions.In this study 20 consecutive patients with inflammatory demyelinating lesions were retrospectively evaluated of whom 10 patients featured progressive disease and 10 a stable lesion load. 3 mm transversal FLAIRfusion imaging was processed and archived. Image processing was performed through landmark-based 3D co-registration of the previous and current isotropic FLAIR examination followed by inversion of image contrast. Thereby, the hyperintense signals of the unchanged MS plaques extinguish each other, while newly developed lesions appear bright on FLAIRfusion. Diagnostic performance was evaluated by 4 experienced readers. Consensus reading supplied the reference standard. Sensitivity, specificity, NPV (negative predictive value), PPV (positive predictive value), interreader agreement and reading time were the outcome measures analyzed.Combined sensitivity was 100% at a specificity of 88.2%, with PPV ranging from 83.3% to 90.1% and NPV at 100%. Reading time was nearly 5-fold faster than conventional side by side comparison (35.6 s vs. 163.7 s, p < 0.001). Cohen's kappa was excellent (>0.75; p < 0.001) and Cronbach's alpha was 0.994.FLAIRfusion provides reliable detection of newly developed MS lesions along with strong interreader agreement across all levels of expertise in 35 s of reading time.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Dörfler, Arnd Prof. Dr.
Neuroradiologische Abteilung im Radiologischen Institut
Kloska, Stephan apl. Prof. Dr.
Neuroradiologische Abteilung im Radiologischen Institut
Linker, Ralf PD Dr.
Stiftungsprofessur für Neuroimmunologie
Lücking, Hannes Dr. med.
Neuroradiologische Abteilung im Radiologischen Institut
Schmidt, Manuel Dr. med.
Neuroradiologische Abteilung im Radiologischen Institut
Uder, Michael Prof. Dr.
Lehrstuhl für Diagnostische Radiologie


Zitierweisen

APA:
Schmidt, M., Linker, R., Lang, S., Lücking, H., Engelhorn, T., Kloska, S.,... Dankerl, P. (2017). FLAIRfusion Processing with Contrast Inversion : Improving Detection and Reading Time of New Cerebral MS Lesions. Clinical Neuroradiology. https://dx.doi.org/10.1007/s00062-017-0567-y

MLA:
Schmidt, Manuel, et al. "FLAIRfusion Processing with Contrast Inversion : Improving Detection and Reading Time of New Cerebral MS Lesions." Clinical Neuroradiology (2017).

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Zuletzt aktualisiert 2018-07-10 um 02:30