Chronic recurrent multifocal osteomyelitis in association with pyoderma gangraenosum

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Details zur Publikation

Autorinnen und Autoren: Wurm M, Brecht I, Lell M, Brunner K, Mitsimponas KT, Chada M, Jahn J, Neukam FW, von Wilmowsky C
Zeitschrift: BMC Oral Health
Jahr der Veröffentlichung: 2016
Band: 16
Heftnummer: 1
Seitenbereich: 85
ISSN: 1472-6831


Chronic recurrent multifocal osteomyelitis (CRMO) is a rare acquired inflammatory skeletal disorder of unknown origin. CRMO was first described by Gideon in 1972 and mainly affects children and young adults of female gender. The CRMO is part of the clinical picture of non-bacterial Osteomyelitis (NBO) and typically presents a relapsing recurring course with both remission and spontaneous exacerbation. CRMO is typically encountered in the limbs and the metaphysis of long bones in particular. Usually the clinical symptoms include painful swellings of the affected regions. This case report describes the rare case of a CRMO of the mandible in association with pyoderma gangraenosum.A 14-year old female caucasian patient, residing in the south of Germany, presented in the oncological outpatient clinic of our Department of Paediatrics and Adolescent Medicine in June 2014 complaining of increasing neck pain and progressive swelling at her left cheek ongoing for about 6 weeks. These symptoms had been occurring quarterly for 4 years, but had never been as pronounced. Blood biochemistry showed a moderately elevated CRP (35 mg/l) and a significantly increased blood sedimentation rate (BSR 48/120 mm). The panoramic radiograph, however, revealed a bone alteration in the left mandibular region. Further investigations confirmed the diagnosis of CRMO.The present case underlines the fact that rare diseases might occasionally present with even more rare symptoms. These occasions can obviously be considered to present a considerable diagnostic challenge.

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Lell, Michael Prof. Dr.
Medizinische Fakultät
Neukam, Friedrich Wilhelm Prof. Dr. Dr.
Lehrstuhl für Zahnmedizin, insbesondere Mund-, Kiefer-, und Gesichtschirurgie
von Wilmowsky, Cornelius PD Dr.
Mund-, Kiefer- und Gesichtschirurgische Klinik
Wurm, Matthias Dr.
Mund-, Kiefer- und Gesichtschirurgische Klinik

Einrichtungen weiterer Autorinnen und Autoren

Royal Free Hospital


Wurm, M., Brecht, I., Lell, M., Brunner, K., Mitsimponas, K.T., Chada, M.,... von Wilmowsky, C. (2016). Chronic recurrent multifocal osteomyelitis in association with pyoderma gangraenosum. BMC Oral Health, 16(1), 85.

Wurm, Matthias, et al. "Chronic recurrent multifocal osteomyelitis in association with pyoderma gangraenosum." BMC Oral Health 16.1 (2016): 85.


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