Influence of therapy on risk of cancer in rheumatoid arthritis. Pathophysiological principles

Waldner M, Strangfeld A, Aringer M (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Zeitschrift für Rheumatologie Springer Verlag

Book Volume: 75

Pages Range: 13-21

Journal Issue: 1

DOI: 10.1007/s00393-015-0033-7

Abstract

The increased incidence of certain tumor entities in chronic inflammation and infections as well as the increased tumor risk under immunosuppression, illustrate the multiple and complex influences of the immune system on tumor pathogenesis. It is therefore conceivable that immunomodulatory therapy for rheumatoid arthritis (RA) could also influence the risk of malignancies, apart from treating the underlying disease. Basic scientific research studies have identified various signal transduction pathways that are relevant for tumorigenesis and tumor defense mechanisms. This review presents the current knowledge on the effects of the immune system on the occurrence of cancer and tries, where possible, to relate it to specific treatment options.

Authors with CRIS profile

Maximilian Waldner Lehrstuhl für Innere Medizin I

Involved external institutions

Technische Universität Dresden DE Germany (DE) Deutsches Rheuma-Forschungszentrum (DRFZ) DE Germany (DE)

How to cite

APA:

Waldner, M., Strangfeld, A., & Aringer, M. (2016). Influence of therapy on risk of cancer in rheumatoid arthritis. Pathophysiological principles. Zeitschrift für Rheumatologie, 75(1), 13-21. https://doi.org/10.1007/s00393-015-0033-7

MLA:

Waldner, Maximilian, A. Strangfeld, and Martin Aringer. "Influence of therapy on risk of cancer in rheumatoid arthritis. Pathophysiological principles." Zeitschrift für Rheumatologie 75.1 (2016): 13-21.

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