Serum Heme Oxygenase-1 and BMP-7 Are Potential Biomarkers for Bone Metabolism in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis

Journal article


Publication Details

Author(s): Yuan TL, Chen J, Tong YL, Zhang Y, Liu YY, Wei JCC, Liu Y, Zhao Y, Herrmann M
Journal: BioMed Research International
Publication year: 2016
Volume: 2016
Pages range: 7870925
ISSN: 2314-6133


Abstract

Backgrounds. Heme oxygenase-1 (HO-1) has been reported to play a regulatory role in osteoclastogenesis. Bone morphogenetic protein (BMP) pathways induce osteoblastic differentiation and bone remodeling. Aims. To identify serum levels of HO-1, BMP-7, and Runt related-transcription factor 2 (Runx2) in patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS) and to investigate the relationships between HO-1, BMP-7, Runx2, and other common biomarkers for bone metabolism. Results. Serum levels of HO-1 and BMP-7 were revealed to be significantly higher in patients with RA or AS than in healthy controls (p < 0.01). In RA group, HO-1 was positively correlated with BMP-7, Runx2, and tartrate-resistant acid phosphatase-5b (TRAP-5b) (p < 0.05, resp.), BMP-7 was positively correlated with Runx2 and TRAP-5b (p < 0.05, resp.), and Runx2 was negatively correlated with N-terminal midfragment of osteocalcin (NMID) (p < 0.05). In AS group, we observed identical correlation between HO-1 and BMP-7, but opposite correlations between BMP-7 and TRAP-5b and between Runx2 and NMID, when comparing with the RA cohort. Conclusion. Our findings suggest that HO-1 and BMP-7 are potential biomarkers for bone metabolism in patients with RA and AS. The different correlations between the bone markers point to distinct differences in bone remodeling pathways in the two types of arthritis.


FAU Authors / FAU Editors

Herrmann, Martin Prof. Dr.
Medizinische Klinik 3 - Rheumatologie und Immunologie


External institutions with authors

Chung Shan Medical University / 中山醫學大學
Sichuan University (SCU) / 四川大学


How to cite

APA:
Yuan, T.-L., Chen, J., Tong, Y.-L., Zhang, Y., Liu, Y.-Y., Wei, J.C.-C.,... Herrmann, M. (2016). Serum Heme Oxygenase-1 and BMP-7 Are Potential Biomarkers for Bone Metabolism in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis. BioMed Research International, 2016, 7870925. https://dx.doi.org/10.1155/2016/7870925

MLA:
Yuan, Tong-Ling, et al. "Serum Heme Oxygenase-1 and BMP-7 Are Potential Biomarkers for Bone Metabolism in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis." BioMed Research International 2016 (2016): 7870925.

BibTeX: 

Last updated on 2019-02-04 at 08:48