Modeling of Drug Release From Collagen Matrices

Beitrag in einer Fachzeitschrift

Details zur Publikation

Autorinnen und Autoren: Radu AF, Bause M, Knabner P, Lee G, Friess W
Zeitschrift: Journal of Pharmaceutical Sciences
Verlag: Wiley-Blackwell
Jahr der Veröffentlichung: 2002
Band: 91
Heftnummer: 4
Seitenbereich: 964-972
ISSN: 0022-3549


Drug release from collagen matrices is in most cases governed by diffusion from swollen matrices but also enzymatic matrix degradation or hydrophobic drug/ collagen interactions may contribute. To reduce water uptake and to prolong the release, insoluble collagen matrices have been chemically or dehydrothermally cross-linked. Assuming Fickian diffusion a one-dimensional model was developed and tested that allows description of water penetration, swelling and drug release and that may be expanded considering a subsequent erosion process or interactions. Swelling is described by a volume balance. For dry collagen matrices crosslinked by thermal treatment the existence of a moving front separating the polymer from a gel phase was considered, and a convective term induced by the volume expansion was incorporated. The resulting moving boundary problem was solved using a method based on biquadratic finite elements in both space and time that is stable, shows high accuracy, and is suitable for solving problems with a singularity at the initial time point. The model was verified for insoluble collagen matrices at different crosslinking degrees for both chemical and thermal treatment. For constant diffusion coefficients a close form of the solution was derived yielding equivalent results to the numerical approach. © 2002 Wiley-Liss, Inc.

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Knabner, Peter Prof. Dr.
Lehrstuhl für Angewandte Mathematik (Modellierung und Numerik)
Lee, Geoffrey Prof.
Lehrstuhl für Pharmazeutische Technologie

Einrichtungen weiterer Autorinnen und Autoren

University of Bergen / Universitetet i Bergen


Radu, A.F., Bause, M., Knabner, P., Lee, G., & Friess, W. (2002). Modeling of Drug Release From Collagen Matrices. Journal of Pharmaceutical Sciences, 91(4), 964-972.

Radu, Adrian Florin, et al. "Modeling of Drug Release From Collagen Matrices." Journal of Pharmaceutical Sciences 91.4 (2002): 964-972.


Zuletzt aktualisiert 2019-09-07 um 14:29