Modeling of Drug Release From Collagen Matrices

Journal article

Publication Details

Author(s): Radu AF, Bause M, Knabner P, Lee G, Friess W
Journal: Journal of Pharmaceutical Sciences
Publisher: Wiley-Blackwell
Publication year: 2002
Volume: 91
Journal issue: 4
Pages range: 964-972
ISSN: 0022-3549


Drug release from collagen matrices is in most cases governed by diffusion from swollen matrices but also enzymatic matrix degradation or hydrophobic drug/ collagen interactions may contribute. To reduce water uptake and to prolong the release, insoluble collagen matrices have been chemically or dehydrothermally cross-linked. Assuming Fickian diffusion a one-dimensional model was developed and tested that allows description of water penetration, swelling and drug release and that may be expanded considering a subsequent erosion process or interactions. Swelling is described by a volume balance. For dry collagen matrices crosslinked by thermal treatment the existence of a moving front separating the polymer from a gel phase was considered, and a convective term induced by the volume expansion was incorporated. The resulting moving boundary problem was solved using a method based on biquadratic finite elements in both space and time that is stable, shows high accuracy, and is suitable for solving problems with a singularity at the initial time point. The model was verified for insoluble collagen matrices at different crosslinking degrees for both chemical and thermal treatment. For constant diffusion coefficients a close form of the solution was derived yielding equivalent results to the numerical approach. © 2002 Wiley-Liss, Inc.

FAU Authors / FAU Editors

Knabner, Peter Prof. Dr.
Lehrstuhl für Angewandte Mathematik (Modellierung und Numerik)
Lee, Geoffrey Prof.
Lehrstuhl für Pharmazeutische Technologie

External institutions with authors

University of Bergen

How to cite

Radu, A.F., Bause, M., Knabner, P., Lee, G., & Friess, W. (2002). Modeling of Drug Release From Collagen Matrices. Journal of Pharmaceutical Sciences, 91(4), 964-972.

Radu, Adrian Florin, et al. "Modeling of Drug Release From Collagen Matrices." Journal of Pharmaceutical Sciences 91.4 (2002): 964-972.


Last updated on 2019-09-07 at 14:29