The Effect of Long-term Antiglaucomatous Drug Administration on Central Corneal Thickness

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Schrems W, Schrems-Hösl LM, Mardin CY, Horn F, Jünemann A, Kruse F, Braun JM, Lämmer R
Zeitschrift: Journal of Glaucoma
Jahr der Veröffentlichung: 2016
Band: 25
Heftnummer: 3
Seitenbereich: 274-80
ISSN: 1057-0829


Abstract


To evaluate rates of changes per year of central corneal thickness after antiglaucomatous drug administration with ?-blockers, prostaglandin analogs, and carbonic anhydrase inhibitors monotherapy and combined topical antiglaucomatous therapy, in a cohort of patients with ocular hypertension, glaucoma suspects, and patients with perimetric glaucoma as compared with normal controls.This retrospective single-center study included 130 eyes as healthy controls, 121 eyes of ocular hypertensive patients, 105 eyes of glaucoma suspects, and 49 eyes of perimetric glaucoma patients. All patients underwent standard automated perimetry, 24-hour intraocular pressure profile, optic disc photography, and optical coherence pachymetry (OCP; Heidelberg Engineering). The cohort was divided into 8 groups on the basis of topical antiglaucomatous medication. Linear regression analysis was conducted to analyze the relationship between central corneal thickness and exposure to antiglaucomatous medication during the follow-up.Central corneal thickness did not change during the follow-up for investigated diagnostic subgroups. There was a statistically significant decrease in central corneal thickness for eyes treated with prostaglandin monotherapy (-3.1 ?m/y for left eye), and a combined therapy with prostaglandins, carbonic anhydrase inhibitors, and ?-blockers (-5.8 and -3.8 ?m/y for right and left eye, respectively).We recommend regular measurements before and during therapy with prostaglandin monotherapy and a combined therapy with prostaglandins, carbonic anhydrase inhibitors, and ?-blockers. Follow-up intraocular pressure measurements may be underestimated for eyes treated with the aforementioned treatment regimens if central corneal thickness is not measured on a regular basis.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Horn, Folkert Dr. rer. biol. hum.
Augenklinik
Jünemann, Anselm Prof. Dr.
Medizinische Fakultät
Kruse, Friedrich Prof. Dr.
Lehrstuhl für Augenheilkunde
Schrems, Wolfgang Dr. med.
Augenklinik
Schrems-Hösl, Laura-Maria Dr. med.
Augenklinik


Zitierweisen

APA:
Schrems, W., Schrems-Hösl, L.-M., Mardin, C.Y., Horn, F., Jünemann, A., Kruse, F.,... Lämmer, R. (2016). The Effect of Long-term Antiglaucomatous Drug Administration on Central Corneal Thickness. Journal of Glaucoma, 25(3), 274-80. https://dx.doi.org/10.1097/IJG.0000000000000190

MLA:
Schrems, Wolfgang, et al. "The Effect of Long-term Antiglaucomatous Drug Administration on Central Corneal Thickness." Journal of Glaucoma 25.3 (2016): 274-80.

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Zuletzt aktualisiert 2018-06-10 um 03:12