The OMERACT Ultrasound Group: A Report from the OMERACT 2016 Meeting and Perspectives

Terslev L, Iagnocco A, Bruyn GAW, Naredo E, Vojinovic J, Collado P, Damjanov N, Filer A, Filippou G, Finzel S, Gandjbakhch F, Ikeda K, Keen HI, Kortekaas MC, Magni-Manzoni S, Ohrndorf S, Pineda C, Ravagnani V, Richards B, Sahbudin I, Schmidt WA, Siddle HJ, Stoenoiu MS, Szkudlarek M, Tzaribachev N, D'Agostino MA (2017)

Publication Type: Journal article

Publication year: 2017

Journal

DOI: 10.3899/jrheum.161240

Abstract

To provide an update from the Outcome Measures in Rheumatology (OMERACT) Ultrasound Working Group on the progress for defining ultrasound (US) minimal disease activity threshold at joint level in rheumatoid arthritis (RA) and for standardization of US application in juvenile idiopathic arthritis (JIA).For minimal disease activity, healthy controls (HC) and patients with early arthritis (EA) who were naive to disease-modifying antirheumatic drugs were recruited from 2 centers. US was performed of the hands and feet, and scored semiquantitatively (0-3) for synovial hypertrophy (SH) and power Doppler (PD). Synovial effusion (SE) was scored a binary variable. For JIA, a Delphi approach and subsequent validation in static images and patient-based exercises were used to developed preliminary definitions for synovitis and a scoring system.For minimal disease activity, 7% HC had at least 1 joint abnormality versus 30% in the EA group. In HC, the findings of SH and PD were predominantly grade 1 whereas all grades were seen in the EA cohort, but SE was rare. In JIA, synovitis can be diagnosed based on B-mode findings alone because of the presence of physiological vascularization. A semiquantitative scoring system (0-3) for synovitis for both B-mode and Doppler were developed in which the cutoff between Doppler grade 2 and grade 3 was 30%.The first step has been taken to define the threshold for minimal disease activity in RA by US and to define and develop a scoring system for synovitis in JIA. Further steps are planned for the continuous validation of US in these areas.

Authors with CRIS profile

Involved external institutions

Hospital Universitario Severo Ochoa Spain (ES) University of Belgrade / Универзитет у Београду Serbia (RS) University of Birmingham United Kingdom (GB) Università degli Studi di Siena (UNISI) / University of Siena Italy (IT) University of Paris 6 - Pierre et Marie Curie / Université Paris VI Pierre et Marie Curie (UPMC) France (FR) Chiba University Hospital Japan (JP) Royal Perth Hospital Australia (AU) Leiden University Netherlands (NL) Ospedale Pediatrico Bambino Gesu Italy (IT) Humboldt-Universität zu Berlin Germany (DE) Hospital Carlo Poma Italy (IT) Royal Prince Alfred Hospital Australia (AU) Immanuel Krankenhaus Berlin Germany (DE) University of Leeds United Kingdom (GB) Cliniques universitaires Saint-Luc (CHU St-Luc) Belgium (BE) Zealand University Hospital Denmark (DK) PRI Pediatric Rheumatology Research Institute GmbH Germany (DE) Hôpital Ambroise-Paré France (FR) Rigshospitalet Denmark (DK) University of Turin / Università degli Studi di Torino (UNITO) Italy (IT) MC Groep Netherlands (NL) Fundación Jiménez Díaz Spain (ES) University of Nish Serbia (RS)

How to cite

APA:

Terslev, L., Iagnocco, A., Bruyn, G.A.W., Naredo, E., Vojinovic, J., Collado, P.,... D'Agostino, M.-A. (2017). The OMERACT Ultrasound Group: A Report from the OMERACT 2016 Meeting and Perspectives. Journal of Rheumatology. https://doi.org/10.3899/jrheum.161240

MLA:

Terslev, Lene, et al. "The OMERACT Ultrasound Group: A Report from the OMERACT 2016 Meeting and Perspectives." Journal of Rheumatology (2017).

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