Putting the new ILAE classification of focal cortical dysplasia into practice in western China

Huang C, Zhang H, Chi XS, Chen N, Gong J, Zhou Q, Blümcke I, Zhou D, Li JM (2017)


Publication Type: Journal article

Publication year: 2017

Journal

Book Volume: 51

Pages Range: 133-138

DOI: 10.1016/j.seizure.2017.07.008

Abstract

To re-examine drug-resistant epilepsy cases using the revised 2011 ILAE classification of focal cortical dysplasia (FCD).Patients with drug-resistant epilepsy who have undergone epilepsy surgery in West China Hospital between July 2012 and Jun 2014 were included. Clinical histories, pathological diagnoses, and surgical outcomes were reviewed. A questionnaire was developed to investigate the clinical practice of the new classification. A short-term training program on FCD was carried out to improve pathological diagnosis accuracy.260 consecutive cases (177 male and 83 female) were included. Pathological diagnosis was changed in 70 cases (26.9%) after re-examination. The five most common pathological types were hippocampal sclerosis (19.2%, 50/260), brain tumors (17.7%, 46/260), vascular malformations (16.2%, 42/260), glial scars (11.2%, 29/260) and FCD (10.0%, 26/260). The most common subtype of isolated FCD was FCD IIb (53.8%, 14/26), followed by FCD IIa (42.3%, 11/26) and FCD Ib (3.8%, 1/26). In addition, forty-five cases were diagnosed as associated FCD type III (17.3%, 45/260). Half of patients with FCD achieved Engel class I at two-year follow-up. Questionnaire investigation suggested most participant pathologists lack sufficient knowledge on the new classification. The diagnostic sensitivity for different FCD subtypes was significantly improved by two to six folds after short-term training.FCD is an important etiology of drug-resistant epilepsy in western China. It is essential to provide continuing trainings to improve diagnostic precision of FCD in developing countries.

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How to cite

APA:

Huang, C., Zhang, H., Chi, X.-S., Chen, N., Gong, J., Zhou, Q.,... Li, J.-M. (2017). Putting the new ILAE classification of focal cortical dysplasia into practice in western China. Seizure-European Journal of Epilepsy, 51, 133-138. https://dx.doi.org/10.1016/j.seizure.2017.07.008

MLA:

Huang, Cheng, et al. "Putting the new ILAE classification of focal cortical dysplasia into practice in western China." Seizure-European Journal of Epilepsy 51 (2017): 133-138.

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