Putting the new ILAE classification of focal cortical dysplasia into practice in western China

Journal article


Publication Details

Author(s): Huang C, Zhang H, Chi XS, Chen N, Gong J, Zhou Q, Blümcke I, Zhou D, Li JM
Journal: Seizure-European Journal of Epilepsy
Publication year: 2017
Volume: 51
Pages range: 133-138
ISSN: 1059-1311


Abstract

To re-examine drug-resistant epilepsy cases using the revised 2011 ILAE classification of focal cortical dysplasia (FCD).Patients with drug-resistant epilepsy who have undergone epilepsy surgery in West China Hospital between July 2012 and Jun 2014 were included. Clinical histories, pathological diagnoses, and surgical outcomes were reviewed. A questionnaire was developed to investigate the clinical practice of the new classification. A short-term training program on FCD was carried out to improve pathological diagnosis accuracy.260 consecutive cases (177 male and 83 female) were included. Pathological diagnosis was changed in 70 cases (26.9%) after re-examination. The five most common pathological types were hippocampal sclerosis (19.2%, 50/260), brain tumors (17.7%, 46/260), vascular malformations (16.2%, 42/260), glial scars (11.2%, 29/260) and FCD (10.0%, 26/260). The most common subtype of isolated FCD was FCD IIb (53.8%, 14/26), followed by FCD IIa (42.3%, 11/26) and FCD Ib (3.8%, 1/26). In addition, forty-five cases were diagnosed as associated FCD type III (17.3%, 45/260). Half of patients with FCD achieved Engel class I at two-year follow-up. Questionnaire investigation suggested most participant pathologists lack sufficient knowledge on the new classification. The diagnostic sensitivity for different FCD subtypes was significantly improved by two to six folds after short-term training.FCD is an important etiology of drug-resistant epilepsy in western China. It is essential to provide continuing trainings to improve diagnostic precision of FCD in developing countries.


FAU Authors / FAU Editors

Blümcke, Ingmar Prof. Dr.
Lehrstuhl für Neuropathologie


External institutions with authors

Sichuan University (SCU) / 四川大学


How to cite

APA:
Huang, C., Zhang, H., Chi, X.-S., Chen, N., Gong, J., Zhou, Q.,... Li, J.-M. (2017). Putting the new ILAE classification of focal cortical dysplasia into practice in western China. Seizure-European Journal of Epilepsy, 51, 133-138. https://dx.doi.org/10.1016/j.seizure.2017.07.008

MLA:
Huang, Cheng, et al. "Putting the new ILAE classification of focal cortical dysplasia into practice in western China." Seizure-European Journal of Epilepsy 51 (2017): 133-138.

BibTeX: 

Last updated on 2018-06-10 at 03:11