Treatment Planning Studies in Patient Data With Scanned Carbon Ion Beams for Catheter-Free Ablation of Atrial Fibrillation

Constantinescu A, Lehmann HI, Packer DL, Bert C, Durante M, Graeff C (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Journal of Cardiovascular Electrophysiology Wiley-Blackwell

Book Volume: 27

Pages Range: 335-44

Journal Issue: 3

DOI: 10.1111/jce.12888

Abstract

Catheter ablation with isolation of the pulmonary veins is a common treatment option for atrial fibrillation but still has insufficient success rates and carries several interventional risks. These treatment planning studies assessed if high-dose single fraction treatment with scanned carbon ions (12C) can be reliably delivered for AF ablation, while sparing risk structures and considering respiratory and contractile target motion.Time resolved CT scans of complete respiratory and cardiac cycles of 9 and 5 patients, respectively, were obtained. Ablation lesions and organs at risk for beam delivery were contoured. Single fraction intensity-modulated particle therapy with target doses of 25 and 40 Gy were studied and motion influences on these deliveries mitigated. Respiration had a large influence on lesion displacement (<= 2 cm). End expiration could be exploited as a stable gating window. Smaller, but less predictable, heartbeat displacements (< 6 mm) remained to be mitigated because cardiac contraction resulted in insufficient dose coverage (V95 < 90%) if uncompensated. Repeated irradiation (12C beam rescanning) during breath hold was used to accommodate contractile motion, resulting in good dose coverage. Dose depositions to all organs at risk were carefully examined and did not exceed values for X-ray cancer treatment.Treatment planning of 12C with delivery of physical ionizing radiation doses that have been described to induce complete block is feasible for AF ablation, considering human anatomy, dose constraints, and encasing underlying motion patterns from respiration and cardiac contraction at the LA-PV junction into treatment planning.

Authors with CRIS profile

Christoph Bert Professur für Med. Strahlenphysik

Involved external institutions

GSI Helmholtzzentrum für Schwerionenforschung GmbH DE Germany (DE) Mayo Clinic US United States (USA) (US)

How to cite

APA:

Constantinescu, A., Lehmann, H.I., Packer, D.L., Bert, C., Durante, M., & Graeff, C. (2016). Treatment Planning Studies in Patient Data With Scanned Carbon Ion Beams for Catheter-Free Ablation of Atrial Fibrillation. Journal of Cardiovascular Electrophysiology, 27(3), 335-44. https://doi.org/10.1111/jce.12888

MLA:

Constantinescu, Anna, et al. "Treatment Planning Studies in Patient Data With Scanned Carbon Ion Beams for Catheter-Free Ablation of Atrial Fibrillation." Journal of Cardiovascular Electrophysiology 27.3 (2016): 335-44.

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