Formation of Mefenamic Acid Nanocrystals with Improved Dissolution Characteristics

Journal article


Publication Details

Author(s): Konnerth CG, Braig V, Schmidt J, Lee G, Peukert W, Ito A
Journal: Chemie Ingenieur Technik
Publisher: Wiley-VCH Verlag
Publication year: 2017
Volume: 89
Journal issue: 89
Pages range: 1060-1071
ISSN: 0009-286X
Language: English


Abstract

An industrially feasible formulation approach combining media milling and spray-drying was applied to improve dissolu-
tion characteristics of the poorly soluble drug mefenamic acid (MA). The approach was studied for two MA polymorphs
at different stressing and pH conditions. It was found that final MA product particle sizes are rather determined by the
solid-liquid equilibrium than by mechanical fracture. Obtained drug particles are only composed of the most stable poly-
morph. Direct compressed tablets containing MA nanocrystals exhibit a significant improvement of in vitro dissolution
kinetics as compared to tablets with micronized drug particles.


FAU Authors / FAU Editors

Braig, Veronika
Lehrstuhl für Pharmazeutische Technologie
Konnerth, Christoph-Günther
Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik
Lee, Geoffrey Prof.
Lehrstuhl für Pharmazeutische Technologie
Peukert, Wolfgang Prof. Dr.-Ing.
Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik
Schmidt, Jochen Dr.
Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik


Additional Organisation
Exzellenz-Cluster Engineering of Advanced Materials


Research Fields

C Photonic and Optical Materials
Exzellenz-Cluster Engineering of Advanced Materials


How to cite

APA:
Konnerth, C.-G., Braig, V., Schmidt, J., Lee, G., Peukert, W., & Ito, A. (2017). Formation of Mefenamic Acid Nanocrystals with Improved Dissolution Characteristics. Chemie Ingenieur Technik, 89(89), 1060-1071. https://dx.doi.org/10.1002/cite.201600190

MLA:
Konnerth, Christoph-Günther, et al. "Formation of Mefenamic Acid Nanocrystals with Improved Dissolution Characteristics." Chemie Ingenieur Technik 89.89 (2017): 1060-1071.

BibTeX: 

Last updated on 2018-15-10 at 13:16