Formation of Mefenamic Acid Nanocrystals with Improved Dissolution Characteristics

Konnerth CG, Braig V, Schmidt J, Lee G, Peukert W, Ito A (2017)


Publication Language: English

Publication Type: Journal article

Publication year: 2017

Journal

Publisher: Wiley-VCH Verlag

Book Volume: 89

Pages Range: 1060-1071

Journal Issue: 89

DOI: 10.1002/cite.201600190

Abstract

An industrially feasible formulation approach combining media milling and spray-drying was applied to improve dissolu-
tion characteristics of the poorly soluble drug mefenamic acid (MA). The approach was studied for two MA polymorphs
at different stressing and pH conditions. It was found that final MA product particle sizes are rather determined by the
solid-liquid equilibrium than by mechanical fracture. Obtained drug particles are only composed of the most stable poly-
morph. Direct compressed tablets containing MA nanocrystals exhibit a significant improvement of in vitro dissolution
kinetics as compared to tablets with micronized drug particles.

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How to cite

APA:

Konnerth, C.-G., Braig, V., Schmidt, J., Lee, G., Peukert, W., & Ito, A. (2017). Formation of Mefenamic Acid Nanocrystals with Improved Dissolution Characteristics. Chemie Ingenieur Technik, 89(89), 1060-1071. https://dx.doi.org/10.1002/cite.201600190

MLA:

Konnerth, Christoph-Günther, et al. "Formation of Mefenamic Acid Nanocrystals with Improved Dissolution Characteristics." Chemie Ingenieur Technik 89.89 (2017): 1060-1071.

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