MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation

Anderson S, Poudel KR, Roh-Johnson M, Brabletz T, Yu M, Borenstein-Auerbach N, Grady WN, Bai J, Moens CB, Eisenman RN, Conacci-Sorrell M (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Proceedings of the National Academy of Sciences of the United States of America National Academy of Sciences

Book Volume: 113

Pages Range: E5481-90

Journal Issue: 37

DOI: 10.1073/pnas.1610994113

Abstract

MYC-nick is a cytoplasmic, transcriptionally inactive member of the MYC oncoprotein family, generated by a proteolytic cleavage of full-length MYC. MYC-nick promotes migration and survival of cells in response to chemotherapeutic agents or withdrawal of glucose. Here we report that MYC-nick is abundant in colonic and intestinal tumors derived from mouse models with mutations in the Wnt, TGF-?, and PI3K pathways. Moreover, MYC-nick is elevated in colon cancer cells deleted for FBWX7, which encodes the major E3 ligase of full-length MYC frequently mutated in colorectal cancers. MYC-nick promotes the migration of colon cancer cells assayed in 3D cultures or grown as xenografts in a zebrafish metastasis model. MYC-nick accelerates migration by activating the Rho GTPase Cdc42 and inducing fascin expression. MYC-nick, fascin, and Cdc42 are frequently up-regulated in cells present at the invasive front of human colorectal tumors, suggesting a coordinated role for these proteins in tumor migration.

Authors with CRIS profile

Thomas Brabletz Lehrstuhl für Experimentelle Medizin mit dem Schwerpunkt Molekulare Pathogeneseforschung

Involved external institutions

Fred Hutchinson Cancer Research Center CA Canada (CA) University of Texas Southwestern Medical Center (UT Southwestern) US United States (USA) (US)

How to cite

APA:

Anderson, S., Poudel, K.R., Roh-Johnson, M., Brabletz, T., Yu, M., Borenstein-Auerbach, N.,... Conacci-Sorrell, M. (2016). MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation. Proceedings of the National Academy of Sciences of the United States of America, 113(37), E5481-90. https://doi.org/10.1073/pnas.1610994113

MLA:

Anderson, Sarah, et al. "MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation." Proceedings of the National Academy of Sciences of the United States of America 113.37 (2016): E5481-90.

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