N -(Carboxymethyl)lysine adducts of proteins are ligands for RAGE (receptor for AGE) that activate cell signalling pathways and modulate gene expression

Journal article


Publication Details

Author(s): Kislinger T, Fu C, Huber B, Qu W, Taguchi A, Yan SD, Hofmann MA, Yan SF, Pischetsrieder M, Stern DM, Schmidt AM
Journal: The Journal of biological chemistry
Publisher: American Society for Biochemistry and Molecular Biology
Publication year: 1999
Volume: 274
Pages range: 31740-31749
ISSN: 1083-351X


Abstract


Recent studies suggested that interruption of the interaction of advanced glycation end products (AGEs), with the signal-transducing receptor receptor for AGE (RAGE), by  administration of the soluble, extracellular ligand-binding domain of RAGE, reversed vascular hyperpermeability and suppressed accelerated atherosclerosis in diabetic rodents. Since the precise molecular target of soluble RAGE in those settings was not elucidated, we tested the hypothesis that predominant specific AGEs within the tissues in disorders such as diabetes

and renal failure, Ne-(carboxymethyl)lysine (CML) adducts, are ligands of RAGE. We demonstrate here that physiologically relevant CML modifications of proteins engage cellular RAGE, thereby activating key cell signaling pathways such as NF-kB and modulating gene

expression. Thus, CML-RAGE interaction triggers processes intimately linked to accelerated vascular and inflammatory complications that typify disorders in which inflammation is an established component.



FAU Authors / FAU Editors

Pischetsrieder, Monika Prof. Dr.
Lehrstuhl für Lebensmittelchemie (Henriette-Schmidt-Burkhardt Lehrstuhl)
Yan, Shi Fang


How to cite

APA:
Kislinger, T., Fu, C., Huber, B., Qu, W., Taguchi, A., Yan, S.D.,... Schmidt, A.M. (1999). N -(Carboxymethyl)lysine adducts of proteins are ligands for RAGE (receptor for AGE) that activate cell signalling pathways and modulate gene expression. The Journal of biological chemistry, 274, 31740-31749. https://dx.doi.org/10.1074/jbc.274.44.31740

MLA:
Kislinger, Thomas, et al. "N -(Carboxymethyl)lysine adducts of proteins are ligands for RAGE (receptor for AGE) that activate cell signalling pathways and modulate gene expression." The Journal of biological chemistry 274 (1999): 31740-31749.

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Last updated on 2018-08-08 at 18:24