Effects of targeted therapies on the bone in arthritides

Szentpetery A, Horvath A, Gulyas K, Petho Z, Bhattoa HP, Szanto S, Szucs G, Fitzgerald O, Schett G, Szekanecz Z (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Autoimmunity Reviews Elsevier

DOI: 10.1016/j.autrev.2017.01.014

Abstract

Inflammatory arthritides, such as rheumatoid arthritis (RA) and spondyloarthritides (SpA) have been associated with both localized bone resorption and/or formation, and generalized osteoporosis. Systemic inflammation may be the major driver for bone loss in arthritis. In RA and peripheral SpA the RANK-RANKL-OPG network is involved in bone resorption, while in axial SpA the Wnt-?-catenin axis and its inhibitors (DKK-1, sclerostin) are the most relevant. Targeted therapies including biologics and small molecule tyrosine kinase inhibitors may interfere with inflammatory bone metabolism. Most of these compounds are able to slow down radiographic progression and osteoporosis in arthritides. In very early cases of non-radiological SpA, there may be a window of opportunity allowing to prevent syndesmophyte formation. The inability of targeted therapies to increase the production of DKK-1 and sclerostin may explain the lack of efficacy of TNF inhibitors to halt syndesmophyte formation in SpA. Further clinical trials are needed to better understand the bone effects of targeted therapies.

Authors with CRIS profile

Georg Schett Lehrstuhl für Innere Medizin III

Involved external institutions

University of Debrecen / Debreceni Egyetem HU Hungary (HU) St Vincent's Hospital AU Australia (AU)

How to cite

APA:

Szentpetery, A., Horvath, A., Gulyas, K., Petho, Z., Bhattoa, H.P., Szanto, S.,... Szekanecz, Z. (2017). Effects of targeted therapies on the bone in arthritides. Autoimmunity Reviews. https://doi.org/10.1016/j.autrev.2017.01.014

MLA:

Szentpetery, Agnes, et al. "Effects of targeted therapies on the bone in arthritides." Autoimmunity Reviews (2017).

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