Low-affinity peptides and T-cell selection

Ziegler A, Mueller CA, Böckmann R, Uchanska-Ziegler B (2009)

Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2009

Journal

Trends in Immunology Elsevier

Publisher: Elsevier

Book Volume: 30

Pages Range: 53-60

Journal Issue: 2

DOI: 10.1016/j.it.2008.11.004

Abstract

The dual requirement for T cells to recognize a particular major histocompatibility complex (MHC) antigen presenting a foreign peptide and to lack strong reactivity with a complex of the same molecule when bound to a self-peptide, is attained by thymic positive and negative selection processes, the molecular details of which are currently only partially understood. However, the discovery of the thymoproteasome and our improved understanding of the dynamics of peptide presentation permit us to suggest that the biophysical properties of the MHC:peptide class I complexes engaged in positive T-cell selection will be distinct from those involved in negative selection, hence imposing differential barriers for T cells. © 2008 Elsevier Ltd. All rights reserved.

Authors with CRIS profile

Rainer Böckmann Professur für Computational Biology

Involved external institutions

Freie Universität Berlin DE Germany (DE) Eberhard Karls Universität Tübingen DE Germany (DE)

How to cite

APA:

Ziegler, A., Mueller, C.A., Böckmann, R., & Uchanska-Ziegler, B. (2009). Low-affinity peptides and T-cell selection. Trends in Immunology, 30(2), 53-60. https://doi.org/10.1016/j.it.2008.11.004

MLA:

Ziegler, Andreas, et al. "Low-affinity peptides and T-cell selection." Trends in Immunology 30.2 (2009): 53-60.

BibTeX: Download