Oxidized silicon nanoparticles for radiosensitization of cancer and tissue cells

Journal article
(Original article)


Publication Details

Author(s): Klein S, Dell'Arciprete ML, Wegmann M, Distel L, Neuhuber W, Gonzalez MC, Kryschi C
Journal: Biochemical and Biophysical Research Communications
Publisher: Elsevier
Publication year: 2013
Volume: 434
Journal issue: 2
Pages range: 217-222
ISSN: 0006-291X


Abstract


The applicability of ultrasmall uncapped and aminosilanized oxidized silicon nanoparticles (SiNPs and NH-SiNPs) as radiosensitizer was studied by internalizing these nanoparticles into human breast cancer (MCF-7) and mouse fibroblast cells (3T3) that were exposed to X-rays at a single dose of 3Gy. While SiNPs did not increase the production of reactive oxygen species (ROS) in X-ray treated cells, the NH-SiNPs significantly enhanced the ROS formation. This is due to the amino functionality as providing positive surface charges in aqueous environment. The NH-SiNPs were observed to penetrate into the mitochondrial membrane, wherein these nanoparticles provoked oxidative stress. The NH-SiNPs induced mitochondrial ROS production was confirmed by the determination of an increased malondialdehyde level as representing a gauge for the extent of membrane lipid peroxidation. X-ray exposure of NH-SiNPs incubated MCF-7 and 3T3 cells increased the ROS concentration for 180%, and 120%, respectively. Complementary cytotoxicity studies demonstrate that these silicon nanoparticles are more cytotoxic for MCF-7 than for 3T3 cells. © 2013 Elsevier Inc.



FAU Authors / FAU Editors

Distel, Luitpold Prof. Dr.
Strahlenklinik
Klein, Stefanie Dr.
Lehrstuhl für Physikalische Chemie I
Kryschi, Carola Prof. Dr.
Professur für Physikalische Chemie
Neuhuber, Winfried Prof. Dr.
Lehrstuhl für Anatomie und Zellbiologie
Wegmann, Marc
Lehrstuhl für Physikalische Chemie I


External institutions with authors

Universidad Nacional de La Plata (UNLP)


How to cite

APA:
Klein, S., Dell'Arciprete, M.L., Wegmann, M., Distel, L., Neuhuber, W., Gonzalez, M.C., & Kryschi, C. (2013). Oxidized silicon nanoparticles for radiosensitization of cancer and tissue cells. Biochemical and Biophysical Research Communications, 434(2), 217-222. https://dx.doi.org/10.1016/j.bbrc.2013.03.042

MLA:
Klein, Stefanie, et al. "Oxidized silicon nanoparticles for radiosensitization of cancer and tissue cells." Biochemical and Biophysical Research Communications 434.2 (2013): 217-222.

BibTeX: 

Last updated on 2019-09-04 at 14:50