Oxidized silicon nanoparticles for radiosensitization of cancer and tissue cells
Klein S, Dell'Arciprete ML, Wegmann M, Distel L, Neuhuber W, Gonzalez MC, Kryschi C (2013)
Publication Type: Journal article, Original article
Publication year: 2013
Journal
Original Authors: Klein S., Dell'Arciprete M.L., Wegmann M., Distel L.V.R., Neuhuber W., Gonzalez M.C., Kryschi C.
Publisher: Elsevier
Book Volume: 434
Pages Range: 217-222
Journal Issue: 2
DOI: 10.1016/j.bbrc.2013.03.042
Abstract
The applicability of ultrasmall uncapped and aminosilanized oxidized silicon nanoparticles (SiNPs and NH-SiNPs) as radiosensitizer was studied by internalizing these nanoparticles into human breast cancer (MCF-7) and mouse fibroblast cells (3T3) that were exposed to X-rays at a single dose of 3Gy. While SiNPs did not increase the production of reactive oxygen species (ROS) in X-ray treated cells, the NH-SiNPs significantly enhanced the ROS formation. This is due to the amino functionality as providing positive surface charges in aqueous environment. The NH-SiNPs were observed to penetrate into the mitochondrial membrane, wherein these nanoparticles provoked oxidative stress. The NH-SiNPs induced mitochondrial ROS production was confirmed by the determination of an increased malondialdehyde level as representing a gauge for the extent of membrane lipid peroxidation. X-ray exposure of NH-SiNPs incubated MCF-7 and 3T3 cells increased the ROS concentration for 180%, and 120%, respectively. Complementary cytotoxicity studies demonstrate that these silicon nanoparticles are more cytotoxic for MCF-7 than for 3T3 cells. © 2013 Elsevier Inc.
Authors with CRIS profile
Stefanie Klein
Lehrstuhl für Physikalische Chemie I
Marc Wegmann
Lehrstuhl für Physikalische Chemie I
Luitpold Distel
Department of Radiation Oncology
Winfried Neuhuber
Lehrstuhl für Mikroskopische Anatomie und Molekulare Zellbiologie
Carola Kryschi
Professur für Physikalische Chemie
Involved external institutions
Argentina (AR)How to cite
APA:
Klein, S., Dell'Arciprete, M.L., Wegmann, M., Distel, L., Neuhuber, W., Gonzalez, M.C., & Kryschi, C. (2013). Oxidized silicon nanoparticles for radiosensitization of cancer and tissue cells. Biochemical and Biophysical Research Communications, 434(2), 217-222. https://doi.org/10.1016/j.bbrc.2013.03.042
MLA:
Klein, Stefanie, et al. "Oxidized silicon nanoparticles for radiosensitization of cancer and tissue cells." Biochemical and Biophysical Research Communications 434.2 (2013): 217-222.
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