Persistence with antiepileptic drugs in epilepsy patients treated in neurological practices in Germany
Jacob L, Hamer H, Kostev K (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 73
Pages Range: 204-207
DOI: 10.1016/j.yebeh.2017.06.008
Abstract
The goal of this study was to analyze the persistence with antiepileptic drugs (AED) and associated factors in patients followed in neurological practices in Germany.This study included patients aged 18years or over who received two initial diagnoses of epilepsy and a first prescription of AED between 2007 and 2015 in a neurological practice (index date). The main outcome measure was the rate of AED persistence within five years of the index date. Kaplan-Meier analyses were performed to study treatment persistence as a function of age. A Cox proportional hazards regression model was used to estimate the relationship between non-persistence and demographic/clinical variables.A total of 8192 patients followed in neurological practices were included. After five years of follow-up, 41.1% (<=40years), 45.2%, (41-60years) and 50.1% (>60years) of patients followed in neurological practices were persistent (log-rank p-value<0.001). A negative association was found between discontinuation and age (<=40years vs. >60years: OR=1.19, 95% CI: 1.09-1.31; 41-60years vs. >60years: OR=1.10, 95% CI: 1.01-1.19). Furthermore, patients receiving old AED (OR=1.16, 95% CI: 1.01-1.34) or gabapentin (OR=1.46, 95% CI: 1.16-1.83) and those diagnosed with depression (OR=1.12, 95% CI: 1.03-1.21) were at a higher risk of non-persistence, whereas those receiving levetiracetam (OR=0.69, 95% CI: 0.60-0.80) or lamotrigine (OR=0.88, 95% CI: 0.79-0.97) and those with dementia (OR=0.74, 95% CI: 0.65-0.83) were at a lower risk.The rate of epilepsy patients persistent with AED was low after five years of treatment. Age, gender, co-morbidities, and drug characteristics were associated with this persistence.
Authors with CRIS profile
Involved external institutions
IMS Health GmbH & Co. OHG
Germany (DE)
University of Paris 5 - René Descartes / Université Paris V René Descartes
France (FR)
Germany (DE)
University of Paris 5 - René Descartes / Université Paris V René Descartes
France (FR)
How to cite
APA:
Jacob, L., Hamer, H., & Kostev, K. (2017). Persistence with antiepileptic drugs in epilepsy patients treated in neurological practices in Germany. Epilepsy and Behavior, 73, 204-207. https://dx.doi.org/10.1016/j.yebeh.2017.06.008
MLA:
Jacob, Louis, Hajo Hamer, and Karel Kostev. "Persistence with antiepileptic drugs in epilepsy patients treated in neurological practices in Germany." Epilepsy and Behavior 73 (2017): 204-207.
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