Effect of Arteriovenous Anastomosis on Blood Pressure Reduction in Patients With Isolated Systolic Hypertension Compared With Combined Hypertension

Ott C, Lobo MD, Sobotka PA, Mahfoud F, Stanton A, Cockcroft J, Sulke N, Dolan E, Van Der Giet M, Hoyer J, Furniss SS, Foran JP, Witkowski A, Januszewicz A, Schoors D, Tsioufis K, Rensing BJ, Saxena M, Scott B, Ng GA, Achenbach S, Schmieder R (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Book Volume: 5

Journal Issue: 12

DOI: 10.1161/JAHA.116.004234

Abstract

Options for interventional therapy to lower blood pressure (BP) in patients with treatment-resistant hypertension include renal denervation and the creation of an arteriovenous anastomosis using the ROX coupler. It has been shown that BP response after renal denervation is greater in patients with combined hypertension (CH) than in patients with isolated systolic hypertension (ISH). We analyzed the effect of ROX coupler implantation in patients with CH as compared with ISH.The randomized, controlled, prospective ROX Control Hypertension Study included patients with true treatment-resistant hypertension (office systolic BP >=140 mm Hg, average daytime ambulatory BP >=135/85 mm Hg, and treatment with >=3 antihypertensive drugs including a diuretic). In a post hoc analysis, we stratified patients with CH (n=31) and ISH (n=11). Baseline office systolic BP (177±18 mm Hg versus 169±17 mm Hg, P=0.163) and 24-hour ambulatory systolic BP (159±16 mm Hg versus 154±11 mm Hg, P=0.463) did not differ between patients with CH and those with ISH. ROX coupler implementation resulted in a significant reduction in office systolic BP (CH: -29±21 mm Hg versus ISH: -22±31 mm Hg, P=0.445) and 24-hour ambulatory systolic BP (CH: -14±20 mm Hg versus ISH: -13±15 mm Hg, P=0.672), without significant differences between the two groups. The responder rate (office systolic BP reduction >=10 mm Hg) after 6 months was not different (CH: 81% versus ISH: 82%, P=0.932).Our data suggest that creation of an arteriovenous anastomosis using the ROX coupler system leads to a similar reduction of office and 24-hour ambulatory systolic BP in patients with combined and isolated systolic hypertension.URL: http://www.clinicaltrials.gov. Unique identifier: NCT01642498.

Authors with CRIS profile

Involved external institutions

University of Leicester United Kingdom (GB) ZNA Middelheim Belgium (BE) Queen Mary, University of London United Kingdom (GB) General Hospital of Athens Hippocrates / Γενικό Νοσοκομείο Αθηνών «Ιπποκράτειο» Greece (GR) Cliniques universitaires Saint-Luc (CHU St-Luc) Belgium (BE) Institute of Cardiology in Warsaw Poland (PL) Royal Brompton Hospital United Kingdom (GB) East Sussex Healthcare NHS Trust United Kingdom (GB) Universitätsklinikum Gießen und Marburg (UKGM) Germany (DE) Charité - Universitätsmedizin Berlin Germany (DE) Connolly Hospital Blanchardstown / Ospidéal Uí Chonghaile, Baile Bhlainséir Ireland (IE) Eastbourne District General Hospital United Kingdom (GB) Cardiff University United Kingdom (GB) Royal College of Surgeons in Ireland (RCSI) Ireland (IE) Universitätsklinikum des Saarlandes (UKS) Germany (DE) ROX Medical United States (USA) (US) St. Antonius Ziekenhuis Netherlands (NL)

How to cite

APA:

Ott, C., Lobo, M.D., Sobotka, P.A., Mahfoud, F., Stanton, A., Cockcroft, J.,... Schmieder, R. (2016). Effect of Arteriovenous Anastomosis on Blood Pressure Reduction in Patients With Isolated Systolic Hypertension Compared With Combined Hypertension. Journal of the American Heart Association, 5(12). https://doi.org/10.1161/JAHA.116.004234

MLA:

Ott, Christian, et al. "Effect of Arteriovenous Anastomosis on Blood Pressure Reduction in Patients With Isolated Systolic Hypertension Compared With Combined Hypertension." Journal of the American Heart Association 5.12 (2016).

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