Dynamic processes in biological membrane mimics revealed by quasielastic neutron scattering.

Beitrag in einer Fachzeitschrift

Details zur Publikation

Autor(en): Lautner L, Pluhackova K, Barth N, Seydel T, Lohstroh W, Böckmann R, Unruh T
Zeitschrift: Chemistry and physics of lipids
Jahr der Veröffentlichung: 2017
ISSN: 1873-2941
Sprache: Englisch


Neutron scattering is a powerful tool to study relaxation processes in biological membrane mimics in space and time. Combining different inelastic and quasielastic neutron scattering techniques, a large dynamic range can be covered: from atomic to mesoscopic lengths and from femto- to some hundreds of nanoseconds in time. This allows studies on e.g. the diffusion of lipids, the membrane undulation motions, the dispersion of sound waves in membranes as well as the mutual interactions of membrane constituents such as lipids, proteins, and additives. In particular, neutron scattering provides a quite direct experimental approach to the inter-atomic and inter-molecular potentials on length and time scales which are perfectly accessible by molecular dynamics (MD) simulations. Neutron scattering experiments may thus substantially support the further refinement of biomolecular force fields for MD simulations by supplying structural and dynamical information with high spatial and temporal resolution. In turn, MD simulations support the interpretation of neutron scattering data. The combination of both, neutron scattering experiments and MD simulations, yields an unprecedented insight into the molecular interactions governing the structure and dynamics of biological membranes. This review provides an overview of the molecular dynamics in biological membrane mimics as revealed by neutron scattering. It focuses on the latest findings such as the fundamental molecular mechanism of lateral lipid diffusion as well as the influence of additives and proteins on the short-time dynamics of lipids. Special emphasis is placed on the comparison of recent neutron scattering and MD simulation data with respect to molecular membrane dynamics on the pico- to nanosecond time scale.

FAU-Autoren / FAU-Herausgeber

Barth, Nicolai
Juniorprofessur für Bioinformatik
Böckmann, Rainer Prof. Dr.
Professur für Computational Biology
Lautner, Lisa
Professur für Nanomaterialcharakterisierung (Streumethoden)
Pluhackova, Kristyna
Professur für Computational Biology
Unruh, Tobias Prof. Dr.
Professur für Nanomaterialcharakterisierung (Streumethoden)

Zusätzliche Organisationseinheit(en)
Exzellenz-Cluster Engineering of Advanced Materials

Autor(en) der externen Einrichtung(en)
Institute Laue-Langevin (ILL)
Technische Universität München (TUM)


Lautner, L., Pluhackova, K., Barth, N., Seydel, T., Lohstroh, W., Böckmann, R., & Unruh, T. (2017). Dynamic processes in biological membrane mimics revealed by quasielastic neutron scattering. Chemistry and physics of lipids. https://dx.doi.org/10.1016/j.chemphyslip.2017.05.009

Lautner, Lisa, et al. "Dynamic processes in biological membrane mimics revealed by quasielastic neutron scattering." Chemistry and physics of lipids (2017).


Zuletzt aktualisiert 2018-10-08 um 18:08