Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss

Journal article


Publication Details

Author(s): Lucas S, Omata Y, Hofmann J, Böttcher M, Iljazovic A, Sarter K, Albrecht O, Schulz O, Krishnacoumar B, Krönke G, Herrmann M, Mougiakakos D, Strowig T, Schett G, Zaiss M
Journal: Nature Communications
Publication year: 2018
Volume: 9
Journal issue: 1
Pages range: 55
ISSN: 2041-1723


Abstract


Microbial metabolites are known to modulate immune responses of the host. The main metabolites derived from microbial fermentation of dietary fibers in the intestine, short-chain fatty acids (SCFA), affect local and systemic immune functions. Here we show that SCFA are regulators of osteoclast metabolism and bone mass in vivo. Treatment of mice with SCFA as well as feeding with a high-fiber diet significantly increases bone mass and prevents postmenopausal and inflammation-induced bone loss. The protective effects of SCFA on bone mass are associated with inhibition of osteoclast differentiation and bone resorption in vitro and in vivo, while bone formation is not affected. Mechanistically, propionate (C3) and butyrate (C4) induce metabolic reprogramming of osteoclasts resulting in enhanced glycolysis at the expense of oxidative phosphorylation, thereby downregulating essential osteoclast genes such as TRAF6 and NFATc1. In summary, these data identify SCFA as potent regulators of osteoclast metabolism and bone homeostasis.



FAU Authors / FAU Editors

Böttcher, Martin Dr. rer. nat.
Medizinische Klinik 5 - Hämatologie und Internistische Onkologie
Herrmann, Martin Prof. Dr.
Medizinische Klinik 3 - Rheumatologie und Immunologie
Hofmann, Jörg Dr.
Lehrstuhl für Biochemie
Krönke, Gerhard Prof. Dr. med.
Medizinische Klinik 3 - Rheumatologie und Immunologie
Mougiakakos, Dimitrios
Professur für Hämatologie/Onkologie mit dem Schwerpunkt Tumorimmunologie
Schett, Georg Prof. Dr. med.
Lehrstuhl für Innere Medizin III
Zaiss, Mario PD Dr.
Medizinische Klinik 3 - Rheumatologie und Immunologie


External institutions with authors

Helmholtz-Zentrum für Infektionsforschung (HZI)


How to cite

APA:
Lucas, S., Omata, Y., Hofmann, J., Böttcher, M., Iljazovic, A., Sarter, K.,... Zaiss, M. (2018). Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss. Nature Communications, 9(1), 55. https://dx.doi.org/10.1038/s41467-017-02490-4

MLA:
Lucas, Sebastien, et al. "Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss." Nature Communications 9.1 (2018): 55.

BibTeX: 

Last updated on 2018-06-10 at 02:41