Autologous chondrocyte implantation (ACI) for cartilage defects of the knee: A guideline by the working group "Clinical Tissue Regeneration" of the German Society of Orthopaedics and Trauma (DGOU)

Niemeyer P, Albrecht D, Andereya S, Angele P, Ateschrang A, Aurich M, Baumann M, Bosch U, Erggelet C, Fickert S, Gebhard H, Gelse K, Guenther D, Hoburg A, Kasten P, Kolombe T, Madry H, Marlovits S, Meenen NM, Mueller PE, Noeth U, Petersen JP, Pietschmann M, Richter W, Rolauffs B, Rhunau K, Schewe B, Steinert A, Steinwachs MR, Welsch GH, Zinser W, Fritz J (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Book Volume: 23

Pages Range: 426-35

Journal Issue: 3

DOI: 10.1016/j.knee.2016.02.001

Abstract

Autologous chondrocyte implantation (ACI) is an established and well-accepted procedure for the treatment of localised full-thickness cartilage defects of the knee.The present review of the working group "Clinical Tissue Regeneration" of the German Society of Orthopaedics and Trauma (DGOU) describes the biology and function of healthy articular cartilage, the present state of knowledge concerning therapeutic consequences of primary cartilage lesions and the suitable indication for ACI.Based on best available scientific evidence, an indication for ACI is given for symptomatic cartilage defects starting from defect sizes of more than three to four square centimetres; in the case of young and active sports patients at 2.5cm(2), while advanced degenerative joint disease needs to be considered as the most important contraindication.The present review gives a concise overview on important scientific background and the results of clinical studies and discusses the advantages and disadvantages of ACI.Non-systematic Review.

Involved external institutions

Universitätsklinikum Freiburg Germany (DE) Klinik im Kronprinzenbau Germany (DE) Universitätsklinikum Regensburg Germany (DE) Berufsgenossenschaftliche Unfallklinik Tübingen (BGU) Germany (DE) Sana Kliniken Leipziger Land Germany (DE) Städtische Kliniken Esslingen Germany (DE) International Neuroscience Institute GmbH (INI) Germany (DE) Gelenkzentrum Zürich GZZ Switzerland (CH) Sportopaedicum Germany (DE) Medizinische Hochschule Hannover (MHH) / Hannover Medical School Germany (DE) Charité - Universitätsmedizin Berlin Germany (DE) Orthopädisch Chirurgisches Centrum Tübingen Germany (DE) DRK Krankenhaus Luckenwalde Germany (DE) Universitätsklinikum des Saarlandes (UKS) Germany (DE) Altonaer Kinderkrankenhaus (AKK) Germany (DE) Ludwig-Maximilians-Universität (LMU) Germany (DE) Evangelisches Waldkrankenhaus Spandau Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) Universitätsklinikum Heidelberg Germany (DE) Viktoria Klinik Bochum Germany (DE) Julius-Maximilians-Universität Würzburg Germany (DE) Hirslanden Klinik Birshof Switzerland (CH) St. Vinzenz-Hospital Germany (DE) Medizinische Universität Wien Austria (AT)

How to cite

APA:

Niemeyer, P., Albrecht, D., Andereya, S., Angele, P., Ateschrang, A., Aurich, M.,... Fritz, J. (2016). Autologous chondrocyte implantation (ACI) for cartilage defects of the knee: A guideline by the working group "Clinical Tissue Regeneration" of the German Society of Orthopaedics and Trauma (DGOU). Knee, 23(3), 426-35. https://doi.org/10.1016/j.knee.2016.02.001

MLA:

Niemeyer, P., et al. "Autologous chondrocyte implantation (ACI) for cartilage defects of the knee: A guideline by the working group "Clinical Tissue Regeneration" of the German Society of Orthopaedics and Trauma (DGOU)." Knee 23.3 (2016): 426-35.

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